Trial · NCT03648437
Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus
NCT03648437, Phase 1, Terminated, University of Oulu
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus. Trials, record NCT03648437. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03648437
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Paracetamol And Ibuprofen/Indomethacin in Closing Patent Ductus Arteriosus
- NCT number
- NCT03648437
- Status
- Terminated
- Phases
- Phase 1
- Enrollment
- 22 participants, actual
- Lead sponsor
- University of Oulu
- Conditions
- Patent Ductus Arteriosus
- Interventions
- Paracetamol 10Mg/mL, 0.45% Sodium Chloride, Ibuprofen, Indomethacin
- First posted
- 2018-08-27
- Last updated
- 2024-10-18
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Ductal closure | Neonatal internsive care unit (NICU) stay up to 12 weeks | Number of patients with ductal contraction without need for other PDA therapies |
| Secondary | Need for ductal therapies | NICU stay up to 12 weeks | Given ductal therapies after the study drug |
| Secondary | Cardiac ultrasound findings | NICU stay up to 12 weeks | Ductal caliber (mm, mm/kg), LA/Ao ratio |
| Secondary | Duration of any ventilation assist | NICU stay up to 12 weeks | The ventilation assist time pediod |
| Secondary | Paracetamol serum levels | Study drug period up to 4 days | Measured paracetamol concentrations (mg/mL) |
| Secondary | Paracetamol side effects | Study drug period plus 7 days, up to 10 days | Observed adverse events linked to study drug |
| Secondary | Long term complications of prematurity | Hospital stay up to 18 weeks | Moderate-to-severe bronchopulmonary dysplasia, intraventricular hemorrhage grade 2-4, moderate to severe necrotizing enterocolitis, retinopathy of prematurity needing therapy |
| Secondary | Other long-term morbidity, and mortality | Hospital stay up to 18 weeks | Other severe diseases |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers5
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03648437
GET https://conductscience.org/api/trials/v1/NCT03648437/registered