Trial · NCT03651427
Cross-sex Hormone Therapy and Neuronal Plasticity
NCT03651427, Not applicable, Unknown, Hospital de Clinicas de Porto Alegre
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Cross-sex Hormone Therapy and Neuronal Plasticity. Trials, record NCT03651427. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03651427
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Cross-sex Hormone Therapy and Neuronal Plasticity
- NCT number
- NCT03651427
- Status
- Unknown
- Phases
- Not applicable
- Enrollment
- 30 participants, estimated
- Lead sponsor
- Hospital de Clinicas de Porto Alegre
- Conditions
- Gender Dysphoria
- Interventions
- Estradiol
- First posted
- 2018-08-29
- Last updated
- 2018-08-29
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Glutamate concentration in the left hippocampus | 90 days | Proton Spectroscopy - magnetic resonance imaging; Glutamate concentration in the left hippocampus will be primarily correlated to working memory scores. |
| Secondary | Cortical Thickness | 90 days | Anatomical magnetic resonance imaging |
| Secondary | Diffusion track imaging | 90 days | Micro-Structural magnetic resonance imaging |
| Secondary | functional connectivity | 90 days | functional magnetic resonance imaging |
| Secondary | Glutamate concentration in the anterior cingulate cortex and left dorsolateral prefrontal cortex | 90 days | Proton spectroscopy - magnetic resonance imaging; Glutamate concentration in the left dorsolateral prefrontal cortex will be correlated to over all measures of cognition and executive functioning. |
| Secondary | Cognition | 90 days | Instrument: Wechsler Adult Intelligence Scale (WAIS) version 3. Subscale: Full Scale Intelligence coefficient. Mean: 100 Standard deviation (SD):15 for Brazilian population. Range of classification: 69 and below - Extremely Low 70-79 - Borderline 80-89 - Low Average 90-109 - Average 110-119 - High Average 120-129 - Superior 130 and above - very superior |
| Secondary | Operational memory | 90 days | Subscale from Wechsler Adult Intelligence Scale (WAIS) version 3. Mean: 100 Standard deviation (SD):15 for Brazilian population. 69 and below - Extremely Low 70-79 - Borderline 80-89 - Low Average 90-109 - Average 110-119 - High Average 120-129 - Superior 130 and above - very superior |
| Secondary | Verbal memory | 90 days | Rey Auditory-Verbal Learning Test (RAVLT). Mean and range for Brazilian population: 1. A1 (Verbal Memory - Immediate recall). Range (in Z-scores): Z \<-1.5 are classified as deficit; Z \>-1.5 are expected 2. A5 (Verbal Memory - immediate recall). Range (in Z-scores): Z \<-1.5 are classified as deficit; Z \>-1.5 are expected 3. A7 (Verbal Memory - late recall). Range in (Z-scores): Z \<-1.5 are classified as deficit; Z \>-1.5 are expected 4. Learning Over Trial (LOT) (Learning capacity). Range (in Z-scores): Z \<-1.5 are classified as deficit; Z \>-1.5 are expected (please, note the reference for Brazilian population in the section "references" where the mean and standard deviation according to Brazilian population are described for each of the subtest; Salgado et al. (2011). |
| Secondary | Language (Verbal Fluency) | 90 days | Verbal Fluency Tests: (FAS) and Animals. Mean and standard deviation (SD) according to age range and years of education: Age range for the test: 16-59 years Score classification according to years of education: 1. From 0 to 8 years of education: Mean: 38.8 SD: 12.0 2. From 9 to 12 years of education: Mean: 40.5 SD: 10.7 3. From 12 to 21 years of education: Mean: 44.7 SD:11.2 Range in Z-scores: Z \<-1.5 are classified as deficit; Z \>-1.5 are expected |
| Secondary | Executive function | 90 days | Stroop Test -Victoria Version. Mean and standard deviation (SD) according to the age range and years of education: For 19-39 years old + 5-8 years of education: Mean: 33.3 SD:11.35 For 19-39 years old + 9 or more years of education: Mean: 41.73 SD: 9.85 For 40-59 years old + 5-8 years of education: Mean: 28 SD: 7.76 For 40-59 years old + 9 or more years of education: Mean: 37.17 SD: 9.98 Range in Z-scores: Z \<-1.5 are classified as deficit; Z \>-1.5 are expected |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 21971775 | RESULT |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests3
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
| Verbal Learning | Secondary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03651427
GET https://conductscience.org/api/trials/v1/NCT03651427/registered