Retraining Neural Pathways Improves Cognitive Skills After A Mild Traumatic Brain Injury
NCT03655782, Not applicable, Recruiting, Perception Dynamics Institute
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Retraining Neural Pathways Improves Cognitive Skills After A Mild Traumatic Brain Injury | ClinicalTrials.gov |
| NCT number | NCT03655782 | ClinicalTrials.gov |
| Status | Recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 90 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Perception Dynamics Institute | ClinicalTrials.gov |
| Conditions | MTBI - Mild Traumatic Brain Injury | ClinicalTrials.gov |
| Interventions | PATH + DigitMemory (DM) neurotraining | ClinicalTrials.gov |
| First posted | 2018-08-31 | ClinicalTrials.gov |
| Last updated | 2026-10-08 | ClinicalTrials.gov |
Registered outcomes 15
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in Visual Working Memory | Immediately before begin intervention and 3, 6, and 12 months later. | Visual Working Memory (VWM) using Test of Information Processing Skills (TIPS), having two distractor tasks to measure Sequential Processing: the subject must remember a sequence of letters, that are shown one at a time for 2 seconds each, for sequences of from 2 up to 9 letters right after seeing the entire sequence of letters. Short Term that are shown one at a time for 2 seconds each, for sequences of from 2 up to 9 letters right after seeing the entire sequence of letters. Short Term VWM is assessed by recalling the correct sequence of letters after counting from 1 to 10 numbers in sequence, starting at different initial numbers, slowly, and after repeating a short sentence with an animal subject for VWM. Delayed Recall is assessed by remembering all animal names in repeated sentences 3 minutes after finish the VWM tests. The TIPS VWM Standardized Percentile Rank goes from \<1% to 99%. | ClinicalTrials.gov |
| Secondary | Change in Processing Speed | Immediately before begin intervention and 3, 6, and 12 months later. | Processing Speed using Wechsler Adult Intelligence Scale (WAIS-4) Processing Speed Index (PSI): requires two subtests: 1) the WAIS Symbol Search subtest which requires subjects to scan a target group (two symbols) and search a group of 5 symbols, indicating whether one of the target symbols appears in the search group, and 2) WAIS Digit Symbol Coding subtest, where the subject fills in boxes below digits with symbols that are paired with them in a key at the top of the page. Both of these subtests are timed for two minutes each. The scaled scores from each subtest are combined to create an overall Processing Speed Index score, that is converted to a standardized percentile. WAIS Processing Speed Index Standardized Percentile Rank goes from \< 0.1% to \> 99%. | ClinicalTrials.gov |
| Secondary | Change in Attentional Focus | Immediately before begin intervention and 3, 6, and 12 months later. | Selective Attention using Delis-Kaplan Executive Function System (DKEFS) Color-Word Interference test measuring time to say color of the printed word that denotes a different color (Stroop test). DKEFS Color-Word Interference Test Standardized Percentile Rank for Inhibition subtest goes from 0.5% to 99.9%. | ClinicalTrials.gov |
| Secondary | Change in Cognitive Flexibility | Immediately before begin intervention and 3, 6, and 12 months later. | Cognitive Flexibility using DKEFS Color-Word Interference test measuring time to switch attention between color of printed word (Stroop test) and printed word when surrounded by a rectangle. DKEFS Color-Word Interference Test standardized scores for Standardized Percentile Rank for Inhibition Switching subtest goes from 0.5% to 99.9%. | ClinicalTrials.gov |
| Secondary | Change in Auditory Working Memory | Immediately before begin intervention and 3, 6, and 12 months later. | Auditory Working Memory (AWM) is assessed using the WAIS-4 Working Memory Index which consists of two subtests: 1) the Digit Span subtest, where the subject has to repeat a list of spoken numbers, requiring the subject to remember subsequently more numbers: in the correct order, backwards, and in numerical sequence on three different subtests, and 2) the Letter-Number Sequencing subtest which requires sequencing subsequently more numbers and letters in the correct numerical and alphabetic sequence. Presentation of the numbers and letters are timed for one second each for these working memory tests. The WAIS Working Memory Index Standardized Percentile Rank goes from \< 0.1% to \> 99.9%. | ClinicalTrials.gov |
| Secondary | Change in Fluid Intelligence | Time Frame: Immediately before begin intervention and 3, 6, and 12 months later. | Assessed using KBIT Matrices test which requires understanding of relationships among multiple choice stimuli. Each abstract item demands nonverbal reasoning and flexibility on applying a problem-solving strategy. Many items also assess the ability to handle several variables simultaneously. The KBIT Standardized Percentile Rank goes from \< 0.1% to \> 99.9%. | ClinicalTrials.gov |
| Secondary | Change in Reading Proficiency | Immediately before begin intervention and 3, 6, and 12 months later. | Using Adult Dyslexia Test, use reading grade level to measure reading proficiency. Evaluates whether a subject's visual processing and phonological processing is markedly, moderately, mildly, or borderline below normal, or is normal or above normal. | ClinicalTrials.gov |
| Secondary | Change in DLPFC Function | Immediately before begin intervention and 3, 6, and 12 months later. | Using the total covariance matrix, voxel-wise MEG source magnitude images that cover the whole brain will be obtained for each subject, and each frequency band, following the Fast-VESTAL procedure, measuring time-locked signals during a working memory N-back task to evaluate improvements in brain function in DLPFC (working memory). | ClinicalTrials.gov |
| Secondary | Change in Precuneus/PCC | Immediately before begin intervention and 3, 6, and 12 months later. | Using the total covariance matrix, voxel-wise MEG source magnitude images that cover the whole brain will be obtained for each subject, and each frequency band, following the Fast-VESTAL procedure, measuring time-locked signals during a working memory N-back task to evaluate improvements in brain function in Precuneus/PCC (attention network). | ClinicalTrials.gov |
| Secondary | Change in ACC Function | Immediately before begin intervention and 3, 6, and 12 months later. | Using the total covariance matrix, voxel-wise MEG source magnitude images that cover the whole brain will be obtained for each subject, and each frequency band, following the Fast-VESTAL procedure, measuring time-locked signals during a working memory N-back task to evaluate improvements in brain function in ACC (attention network). | ClinicalTrials.gov |
| Secondary | Change in V1-MT | Immediately before begin intervention and 3, 6, and 12 months later. | Using the total covariance matrix, voxel-wise MEG source magnitude images that cover the whole brain will be obtained for each subject, and each frequency band, following the Fast-VESTAL procedure, measuring time-locked signals during a working memory N-back task to evaluate improvements in brain function in V1-MT (visual motion network). | ClinicalTrials.gov |
| Secondary | Change in Reading Speed | Immediately before begin intervention and 3, 6, and 12 months later. | Number of words/minute subject can read 6 words of subsequent text from interesting story using computer-based program. | ClinicalTrials.gov |
| Secondary | Change in Post-Concussion Symptoms | Immediately before begin intervention and 3, 6, and 12 months later. | Rivermead Post-Concussion Symptom Questionnaire evaluates 16 symptoms commonly experienced after a concussion, being rated from 0 (not experienced at all) to 4 (a severe problem). The Rivermead PCS evaluates ocular, vestibular, and mental health symptoms of mTBI subject. | ClinicalTrials.gov |
| Secondary | Change in Quality of Life | Immediately before begin intervention and 3, 6, and 12 months later. | ADCS Quality of Life SF-36 questionnaire evaluates subject's general health, activity limitations, emotional health, physical health, social activities, pain, and energy and emotions, having a score from 0-100. | ClinicalTrials.gov |
| Secondary | Change in Brain Injury Visual Symptom Survey (BIVSS) | Immediately before begin intervention and 3, 6, and 12 months later. | BIVSS rates each of 28 visual behaviors by how often each behavior occurs: Never, seldom, occasionally, frequently, or always. The symptoms are in 8 categories: eyesight clarity, visual comfort, doubling, light sensitivity, dry eyes, depth perception, peripheral vision, and reading. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 7
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| 1-Back Task | Secondary outcome | ConductCognition |
| 2-Back Task | Secondary outcome | ConductCognition |
| Digit Span Test | Secondary outcome | ConductCognition |
| Letter-Number Sequencing Task | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Symbol Coding | Secondary outcome | ConductCognition |
| Symbol Scan Task | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)