Trial · NCT03661385
Nitric Oxide During Bypass for Arterial Switch Operation
NCT03661385, Phase 3, Completed, Murdoch Childrens Research Institute
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Nitric Oxide During Bypass for Arterial Switch Operation. Trials, record NCT03661385. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03661385
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Nitric Oxide During Bypass for Arterial Switch Operation
- NCT number
- NCT03661385
- Status
- Completed
- Phases
- Phase 3
- Enrollment
- 300 participants, actual
- Lead sponsor
- Murdoch Childrens Research Institute
- Conditions
- Low Cardiac Output Syndrome, Transposition of Great Vessels
- Interventions
- Nitric Oxide
- First posted
- 2018-09-07
- Last updated
- 2024-04-18
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Major adverse events | 28 days post intervention | The primary outcome is the number of participants with major adverse events (MAEs) within 28 days post-operatively. MAEs include cardiac arrest, emergency chest opening, use of ECMO, and death. |
| Secondary | Length of stay in ICU (hours) | This will be calculated from date and time of admission to ICU to date and time of discharge from ICU in hours up to 28 days | Length of stay in ICU (hours) will be calculated from date and time of admission to ICU date and time of discharge to ICU. |
| Secondary | Length of stay in hospital (days) | 28 days (or until hospital discharge) | Length of stay in hospital (days) will be calculated from date and time of admission to hospital to date and time of discharge to hospital. |
| Secondary | Ventilator-free days | 28 days (or until ICU discharge) | Ventilator-free days will be calculated from date and time of intubation to date and time of extubation. Each day (or part of a day) will be counted as a day. |
| Secondary | Inotrope hours | Number of hours inotropes have been administered during first 28 days post operatively | Inotrope hours will be calculated from data input into REDCAP. |
| Secondary | Dialysis-free days | 28 days (or until ICU discharge) | Dialysis-free days will be calculated from date and time of start of dialysis to date and time of stopping dialysis. Each day (or part of a day) will be counted as a day. |
| Secondary | Inhaled NO hours | Number of hours inhaled NO have been administered during first 28 days post operatively | Inhaled NO hours will be calculated from data input into REDCAP. |
| Secondary | ECMO-free days | 28 days (or until ICU discharge) | ECMO-free days will be calculated from date and time of start of ECMO to date and time of stopping ECMO. Each day (or part of a day) will be counted as a day. |
| Secondary | Closed sternum days | 28 days (or until ICU discharge) | Closed sternum days will be calculated from date and time of start of chest opening (or return to ICU time if delayed chest closure) to date and time of chest closure. Each day (or part of a day) will be counted as a day. |
| Secondary | Composite free-day score | 28 days (or until hospital discharge) | This score is a combination of scores 1-8 to create a composite free-day score. Composite free-day score is a score highlighting the number of days free from post-operative complications including free of hospitalization within the first 28 days post operatively. For each score, the days free of complication will be calculated to create an individual free from score these will be then added together to create an overall free-from score. Higher scores suggest a better outcome (free from hospital and complications). |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers6
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03661385
GET https://conductscience.org/api/trials/v1/NCT03661385/registered