Trial · NCT03679312
The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in COPD
NCT03679312, Phase 1, Phase 2, Completed, University of Alberta
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in COPD. Trials, record NCT03679312. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03679312
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in COPD
- NCT number
- NCT03679312
- Status
- Completed
- Phases
- Phase 1, Phase 2
- Enrollment
- 140 participants, actual
- Lead sponsor
- University of Alberta
- Conditions
- Dyspnea
- Interventions
- Nitric Oxide, Placebo
- First posted
- 2018-09-20
- Last updated
- 2024-01-11
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Peak Workload | Within 20-25 minutes post-dose | Peak workload will be defined as the highest wattage obtained during a 20 s period during the test. |
| Primary | Peak Oxygen Consumption | Within 20-25 minutes post-dose | Peak oxygen consumption will be defined as the highest O2 uptake (reported in ml/kg/min) obtained during a 20 s period during the test. |
| Secondary | Dyspnea (breathlessness) | Assessed every 2-minutes until completion of the exercise trial; anticipating ~10-14 minute tests | Particpants will rate their perceived dyspnea (breathlessness) using the modified Borg 0-10 scale (0 - No breathlessness; 10 - Maximal breathlessness) |
| Secondary | Pulmonary artery systolic pressure | Assessed for five consecutive cardiac cycles and are measured in triplicate during the cardiac ultrasound trial. This will be completed within 4 weeks of enrollment in the study. | Pulmonary artery systolic pressure will be assessed at rest and during exercise |
| Secondary | Emphysema severity score | Emphysema severity score assessed by computed tomography. This will be completed within 4 weeks of enrollment in the study. | Emphysema severity score assessed by computed tomography |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03679312
GET https://conductscience.org/api/trials/v1/NCT03679312/registered