Trial · NCT03733535
Registered outcomes27
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
1 to 20 of 27
Download this page as JSON| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change from baseline airway function measured using 129-Xenon MRI ventilation defect percent | Day 0 and 28 | Changes in VDP |
| Secondary | Change from baseline airway function measured using 129-Xenon MRI ventilation defect percent | Day 0, 14 and 112 | Changes in VDP |
| Secondary | Change from baseline blood eosinophils | Day 0, 14 and 112 | |
| Secondary | Change from baseline forced expiration volume in one second | Day 0, 14, 28 and 112 | Indicator of pulmonary function |
| Secondary | Change from baseline forced vital capacity | Day 0, 14, 28 and 112 | Indicator of pulmonary function |
| Secondary | Change from baseline lung volumes | Day 0, 14, 28 and 112 | Indicator of pulmonary function |
| Secondary | Change from baseline airways resistance | Day 0, 14, 28 and 112 | Indicator of pulmonary function and inflammation |
| Secondary | Change from baseline forced oscillation technique | Day 0, 14, 28 and 112 | Indicator of pulmonary function and inflammation |
| Secondary | Change from baseline lung clearance index | Day 0, 14, 28 and 112 | Indicator of pulmonary function |
| Secondary | Change from baseline fraction exhaled nitric oxide | Day 0, 14, 28 and 112 | Indicator of pulmonary function and inflammation |
| Secondary | Change from baseline in asthma control | Day 0, 28, 56 and 112 | Asthma Control Questionnaire (ACQ-6) is used to evaluate asthma control. The ACQ-6 is scored from 0 to 6, with higher scores indicating more severely uncontrolled asthma. |
| Secondary | Change from baseline in asthma-related quality of life | Day 0, 28, 56 and 112 | Asthma Quality of Life Questionnaire with Standardised Activities (AQLQ(S)) evaluates asthma-related quality of life. The AQLQ(S) is scored from 1-7, with lower scores indicating more severe impairment. |
| Secondary | Change from baseline in daily life and perceived well-being | Day 0, 28, 56 and 112 | St. George's Respiratory Questionnaire (SGRQ) evaluates daily life and perceived well-being in relation to asthma and respiratory conditions. The SGRQ is scored from 0-100 with higher scores indicating more limitations. |
| Secondary | Change from baseline in Clinician Global Impressions of Change | Day 0 and 112 | The Clinical Global Impressions of Change is an indicator of improvement or decline in clinical status from the perspective of the clinician. It is a scale from 1-7, with lower scores indicating more improvement in clinical status. |
| Secondary | Change from baseline in Patient Global Impressions of Change | Day 0 and 112 | The Patient Global Impressions of Change is an indicator of improvement or decline in clinical status from the perspective of the patient. It is a scale from 1-7, with lower scores indicating more improvement in clinical status. |
| Other | Explore univariate correlation and linear regression of MRI ventilation defect percent and asthma control as measured by the Asthma Control Questionnaire | Day 112 | The relationship between ventilation defect percent and asthma control, as measured by the Asthma Control Questionnaire (ACQ-6) will be assessed using a univariate correlation analysis and linear regression. The ACQ-6 is scored from 0 to 6, with higher scores indicating more uncontrolled asthma. |
| Other | Explore univariate correlation and linear regression of MRI ventilation defect percent and asthma-related quality of life as measured by the Asthma Quality of Life Questionnaire | Day 112 | The relationship between ventilation defect percent and asthma-related quality of life as measured by the Asthma Quality of Life Questionnaire with Standardised Activities (AQLQ(S)) will be assessed using a univariate correlation analysis and linear regression. The AQLQ(S) is scored from 1-7, with lower scores indicating more severe impairment. |
| Other | Explore univariate correlation and linear regression of MRI ventilation defect percent and daily life and perceived well-being as measured by the St. George's Respiratory Questionnaire | Day 112 | The relationship between ventilation defect percent and daily life and perceived well-being as measured by the St. George's Respiratory Questionnaire (SGRQ) will be assessed using univariate correlation analysis and linear regression. The SGRQ is scored from 0-100 with higher scores indicating more limitations. |
| Other | Explore univariate correlation and linear regression of MRI ventilation defect percent and forced expiration volume in one second. | Day 112 | The relationship between ventilation defect percent and forced expiration volume in one second will be assessed using univariate correlation analysis and linear regression. This information gives insight into the relationship between pulmonary function and structure. |
| Other | Explore univariate correlation and linear regression of MRI ventilation defect percent and forced vital capacity | Day 112 | The relationship between ventilation defect percent and forced vital capacity will be assessed using univariate correlation analysis and linear regression. This information gives insight into the relationship between pulmonary function and structure. |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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