Trial · NCT03748420

Medication Adherence Clinical Decision Support

NCT03748420, Not applicable, Completed, HealthPartners Institute; results first posted 2024-02-26

3 sourcestrials-2026-11-12-0.4.0

Cite this record

ConductScience Library. Medication Adherence Clinical Decision Support. Trials, record NCT03748420. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03748420

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Medication Adherence Clinical Decision Support
NCT number: NCT03748420
Status: Completed
Phases: Not applicable
Enrollment: 5,421 participants, actual
Lead sponsor: HealthPartners Institute
Conditions: Hyperlipidemia, Hypertension, Diabetes, Medication Nonadherence
Interventions: Adherence Intervention
First posted: 2018-11-20
Last updated: 2024-02-26
Results first posted: 2024-02-26
Limitations and caveats: Because this study was conducted at a single, relatively high-performing medical group, generalizability of results to other care delivery systems or patient populations is uncertain.

Source ClinicalTrials.gov

Registered outcomes6

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Blood Pressure Medication Adherence	12 months after an index visit	Number of patients who achieve a proportion of days covered (PDC) greater than or equal to 80% for at least one antihypertensive medication in each currently prescribed blood pressure medication class at 12 months following the index office visit date.
Primary	Non-Insulin Glycemic Medication Adherence	12 months after an index visit	Number of patients who achieve a proportion of days covered (PDC) greater than or equal to 80% for at least one non-insulin glycemic medication in each currently prescribed glycemic medication class at 12 months following the index office visit date.
Primary	Statin Medication Adherence	12 months after an index visit	Number of patients who achieve a proportion of days covered (PDC) greater than or equal to 80% for a statin medication if currently prescribed at 12 months following the index office visit date.
Primary	Mean Change in Systolic Blood Pressure	12 months after an index visit	Mean change in systolic blood pressure (SBP) from index to the last SBP value within 12 months after the index visit.
Primary	Mean Change in A1c	12 months after an index visit	Mean change in A1c (glycated hemoglobin) value from the index visit to the last lab test within 12 months after the index visit.
Secondary	Clinic-based Medical Care Costs	12 months after an index visit	Change in annual clinic-based medical care costs, defined from the health system perspective.

Source ClinicalTrials.gov

Outcomes6

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Blood Pressure Medication Adherence	12 months after an index visit	Participants that were not at evidence-based goals for blood pressure (BP) and had PDC less than 80% with moderate to high confidence.	Participants	COUNT_OF_PARTICIPANTS
PRIMARY	Non-Insulin Glycemic Medication Adherence	12 months after an index visit	Participants that were not at evidence-based goals for glucose (A1c) and had PDC less than 80% with moderate to high confidence.	Participants	COUNT_OF_PARTICIPANTS
PRIMARY	Statin Medication Adherence	12 months after an index visit	Participants that had PDC less than 80% with moderate to high confidence.	Participants	COUNT_OF_PARTICIPANTS
PRIMARY	Mean Change in Systolic Blood Pressure	12 months after an index visit	Not at evidence-based clinical goals for SBP and had proportion of days covered (PDC) greater than or equal to 80%.	mm Hg	MEAN
PRIMARY	Mean Change in A1c	12 months after an index visit	Participants that were not at evidence-based goals for hemoglobin A1c and had PDC less than 80% with moderate to high confidence.	percentage of glycated hemoglobin	MEAN
SECONDARY	Clinic-based Medical Care Costs	12 months after an index visit	All enrolled participants that were not at evidence-based goals for blood pressure (BP) or glucose and had proportion of days covered (PDC) less than 80% with moderate to high confidence for blood pressure, glucose, or statin medications.	US dollars	MEAN

Source ClinicalTrials.gov

Results by group12

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Blood Pressure Medication Adherence	Usual Care	396		Participants
Blood Pressure Medication Adherence	Adherence Intervention	470		Participants
Non-Insulin Glycemic Medication Adherence	Usual Care	279		Participants
Non-Insulin Glycemic Medication Adherence	Adherence Intervention	296		Participants
Statin Medication Adherence	Usual Care	529		Participants
Statin Medication Adherence	Adherence Intervention	586		Participants
Mean Change in Systolic Blood Pressure	Usual Care	-15.2	95% Confidence Interval -16.7 to -13.6	mm Hg
Mean Change in Systolic Blood Pressure	Adherence Intervention	-13.8	95% Confidence Interval -15.3 to -12.3	mm Hg
Mean Change in A1c	Usual Care	-1.1	95% Confidence Interval -1.2 to -0.9	percentage of glycated hemoglobin
Mean Change in A1c	Adherence Intervention	-1.2	95% Confidence Interval -1.4 to -1.0	percentage of glycated hemoglobin

1 to 10 of 12Source ClinicalTrials.gov

See all 12 results by group

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Usual Care	2,676
Overall Study	STARTED	Adherence Intervention	2,745
Overall Study	COMPLETED	Usual Care	2,421
Overall Study	COMPLETED	Adherence Intervention	2,486
Overall Study	NOT COMPLETED	Usual Care	255
Overall Study	NOT COMPLETED	Adherence Intervention	259

Source ClinicalTrials.gov

Adverse events16

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk
other	Hypoglycemia	Endocrine disorders	Usual Care	16	2,808
other	Hypoglycemia	Endocrine disorders	Adherence Intervention	26	2,879
other	Hypotension	Vascular disorders	Usual Care	22	2,808
other	Hypotension	Vascular disorders	Adherence Intervention	16	2,879
other	Hypokalemia	Metabolism and nutrition disorders	Usual Care	67	2,808
other	Hypokalemia	Metabolism and nutrition disorders	Adherence Intervention	52	2,879
other	Hyperkalemia	Metabolism and nutrition disorders	Usual Care	17	2,808
other	Hyperkalemia	Metabolism and nutrition disorders	Adherence Intervention	12	2,879
other	Hyponatremia	Metabolism and nutrition disorders	Usual Care	15	2,808
other	Hyponatremia	Metabolism and nutrition disorders	Adherence Intervention	28	2,879

1 to 10 of 16Source ClinicalTrials.gov

See all 16 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Usual Care	24	2,808
Total, all-cause mortality	Adherence Intervention	28	2,879
Total, other adverse events	Usual Care	127	2,808
Total, other adverse events	Adherence Intervention	127	2,879
Total, serious adverse events	Usual Care	557	2,808
Total, serious adverse events	Adherence Intervention	559	2,879

Source ClinicalTrials.gov

Papers2

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
37956792	DERIVED	PubMed
39786775	DERIVED	PubMed

Grants1

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

Project	Title	Principal investigators	Organization	Funder	Fiscal years
R01HL136937	A Team-Based and Technology Driven Adherence Intervention to Improve Chronic Disease Outcomes	SPERL-HILLEN, JOANN M	HEALTHPARTNERS INSTITUTE	NATIONAL HEART, LUNG, AND BLOOD INSTITUTE	2018 to 2022

Source NIH RePORTER

Trial comparisons5

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Adherence Intervention vs Usual Care: Blood Pressure Medication Adherence	Trial comparisons
Adherence Intervention vs Usual Care: Non-Insulin Glycemic Medication Adherence	Trial comparisons
Adherence Intervention vs Usual Care: Statin Medication Adherence	Trial comparisons
Adherence Intervention vs Usual Care: deaths from any cause	Trial comparisons
Adherence Intervention vs Usual Care: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Source

Release: trials-2026-11-12-0.4.0
Release manifest SHA-256: 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
Registry capture: 2026-11-12
Results copy, AACT: 2026-03-23
NIH clinical studies file: 2026-11-13

Source ClinicalTrials.gov

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNone stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT03748420

GET https://conductscience.org/api/trials/v1/NCT03748420/registered

API reference For AI assistants