Trial · NCT03762161
A Phase II Study of Lonsurf (TAS-102) in Metastatic Platinum and Checkpoint Inhibitor-resistant Bladder Cancer
NCT03762161, Phase 2, Unknown, Rahul Parikh
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Phase II Study of Lonsurf (TAS-102) in Metastatic Platinum and Checkpoint Inhibitor-resistant Bladder Cancer. Trials, record NCT03762161. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03762161
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Phase II Study of Lonsurf (TAS-102) in Metastatic Platinum and Checkpoint Inhibitor-resistant Bladder Cancer
- NCT number
- NCT03762161
- Status
- Unknown
- Phases
- Phase 2
- Enrollment
- 22 participants, estimated
- Lead sponsor
- Rahul Parikh
- Conditions
- Bladder Cancer
- Interventions
- TAS 102
- First posted
- 2018-12-03
- Last updated
- 2022-03-10
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Clinical benefit rate (complete response+ partial response+ stable disease) | Up to 6 months | Evaluated per Response Evaluation Criteria In Solid Tumors (RECIST) version 1.1 |
| Secondary | Progression-free survival rate (PFS) among participants | Up to 6 months | Evaluated per Response Evaluation Criteria In Solid Tumors (RECIST) version 1.1 |
| Secondary | Overall response rate (ORR) among participants | Up to 12 months | Evaluated per Response Evaluation Criteria In Solid Tumors (RECIST) version 1.1 |
| Secondary | Overall survival rate (OS) among participants | Up to 12 months | Evaluated per Medical Record |
| Secondary | Overall change in patient-reported quality of life outcomes | Up to 26 months | Evaluated per Functional Assessment of Cancer Therapy - Bladder (FACT-Bl) version 4 - quality of life (QOL) questionnaire scores * FACT-Bl total score range is 0-156, derived by the sum of the sub-scales. Higher scores indicate better QOL. * FACT-Bl includes five sub-scales: * Physical Well-being (PWB), score range of 0-28 * Social/Family Well-being (SWB), score range of 0-28 * Emotional Well-being (EWB), score range of 0-24 * Functional Well-being (FWB), score range of 0-28 * Bladder Cancer Subscale (BlCS), score range of 0-48 * Note: Negatively stated items are reversed by subtracting the response from "4". |
| Secondary | Proportion of participants with Grade 3 or higher Adverse and Serious Adverse Events | Up to 26 months | Evaluated per Common Terminology Criteria for Adverse Events (CTCAE) v5.0 |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03762161
GET https://conductscience.org/api/trials/v1/NCT03762161/registered