Trial · NCT03764605
Metformin vs Tolvaptan for Treatment of Autosomal Dominant Polycystic Kidney Disease
NCT03764605, Phase 3, Unknown, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Metformin vs Tolvaptan for Treatment of Autosomal Dominant Polycystic Kidney Disease. Trials, record NCT03764605. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03764605
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Metformin vs Tolvaptan for Treatment of Autosomal Dominant Polycystic Kidney Disease
- NCT number
- NCT03764605
- Status
- Unknown
- Phases
- Phase 3
- Enrollment
- 150 participants, estimated
- Lead sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
- Conditions
- ADPKD
- Interventions
- Metformin, Tolvaptan
- First posted
- 2018-12-05
- Last updated
- 2018-12-07
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Glomerular Filtration Rate (estimated by CKD-Epi formula) variation | 25 months | Primary outcome of the study is to evaluate the difference between Metformin and Tolvaptan in annualized slope of eGFR (CKD-EPI) for individual subjects, that will be calculated using an appropriate baseline and post-randomization assessment. |
| Secondary | Total Kidney Volume variation (measured by non contrast enhanced Kidney CT scan) | 25 months | The key secondary endpoint is the percent change from baseline in htTKV as measured by CT-scan at 24 months. |
| Other | Blood pressure | 36 months | mmHg |
| Other | Post void body weight | 36 months | Kg |
| Other | Change from serum creatinine baseline | 36 months | mg/dl |
| Other | Serum sodium | 36 months | mg/dl |
| Other | Blood venous gas lactate levels | 36 months | mmol/l |
| Other | Bolood Glucose levels | 36 months | mg/dl |
| Other | Vitamin B12 deficency | 36 months | pg/ml |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 38837240 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03764605
GET https://conductscience.org/api/trials/v1/NCT03764605/registered