Trial · NCT03783429
Digoxin Evaluation in Chronic Heart Failure: Investigational Study In Outpatients in the Netherlands
NCT03783429, Phase 4, Completed, University Medical Center Groningen
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Digoxin Evaluation in Chronic Heart Failure: Investigational Study In Outpatients in the Netherlands. Trials, record NCT03783429. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03783429
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Digoxin Evaluation in Chronic Heart Failure: Investigational Study In Outpatients in the Netherlands
- NCT number
- NCT03783429
- Status
- Completed
- Phases
- Phase 4
- Enrollment
- 982 participants, actual
- Lead sponsor
- University Medical Center Groningen
- Conditions
- Heart Failure
- Interventions
- Digoxin, Placebos
- First posted
- 2018-12-21
- Last updated
- 2026-04-27
Source ClinicalTrials.gov
Registered outcomes16
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | To demonstrate whether low-dose digoxin compared to placebo reduces the rate of the composite CV outcome | Median of 3 years | The composite of total worsening heart failure events (with an event defined as a first or recurrent unplanned hospitalization or urgent visit for heart failure) and death from cardiovascular causes (amount of events) |
| Secondary | To determine whether low-dose digoxin compared to placebo reduces the rate of the ranked clinical outcomes: composite of all repeated HF hospitalizations and repeated urgent HF visits | Median of 3 years | composite of all repeated HF hospitalizations and repeated urgent HF visits (amount) |
| Secondary | To determine whether low-dose digoxin compared to placebo reduces the rate of the ranked clinical outcomes: composite of all repeated CV hospitalizations and repeated urgent CV hospital visits | Median of 3 years | composite of all repeated CV hospitalizations and repeated urgent CV hospital visits (amount) |
| Secondary | To determine whether low-dose digoxin compared to placebo reduces the rate of the ranked clinical outcomes: first-time occurrence of any of the composite of CV-mortality, HF hospitalization or urgent HF hospital visit | Median of 3 years | first-time occurrence of any of the composite of CV-mortality, HF hospitalization or urgent HF hospital visit |
| Secondary | To determine whether low-dose digoxin compared to placebo reduces the rate of the ranked clinical outcomes: first-time occurrence of any of the composite of all-cause mortality, HF hospitalization or urgent HF hospital visit | Median of 3 years | first-time occurrence of any of the composite of all-cause mortality, HF hospitalization or urgent HF hospital visit |
| Secondary | To determine whether low-dose digoxin compared to placebo reduces the rate of the ranked clinical outcomes: first-time occurrence of any of the composite of HF hospitalization or urgent HF hospital visit | Median of 3 years | first-time occurrence of any of the composite of HF hospitalization or urgent HF hospital visit |
| Secondary | To determine whether low-dose digoxin compared to placebo reduces the rate of the ranked clinical outcomes: first time event to CV mortality | Median of 3 years | first time event to CV mortality |
| Secondary | To determine whether low-dose digoxin compared to placebo reduces the rate of the ranked clinical outcomes: first-time event to all-cause mortality | Median of 3 years | first-time event to all-cause mortality |
| Other | To determine whether low-dose digoxin compared to placebo improves the exploratory outcomes: all-cause hospitalizations and urgent hospital visits | Median of 3 years | Amount of events per patient years, incidence rate |
| Other | To determine whether low-dose digoxin compared to placebo improves the exploratory outcomes: days alive and out of hospital | Median of 3 years | amount of days alive and out of hospital |
1 to 10 of 16Source ClinicalTrials.gov
See all 16 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03783429
GET https://conductscience.org/api/trials/v1/NCT03783429/registered