Trial · NCT03809156
Upfront Combination Pulmonary Arterial Hypertension Therapy
NCT03809156, Phase 4, Unknown, University of Calgary
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Upfront Combination Pulmonary Arterial Hypertension Therapy. Trials, record NCT03809156. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03809156
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Upfront Combination Pulmonary Arterial Hypertension Therapy
- NCT number
- NCT03809156
- Status
- Unknown
- Phases
- Phase 4
- Enrollment
- 20 participants, estimated
- Lead sponsor
- University of Calgary
- Conditions
- Pulmonary Hypertension
- Interventions
- Riociguat Oral Product
- First posted
- 2019-01-18
- Last updated
- 2020-03-26
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Pulmonary Vascular resistance | 4 and 12 months | Change from baseline to month 4 and month 12 in pulmonary vascular resistance (PVR) as assessed by Right Heart Catheterization. |
| Secondary | Hemodynamic Variables | 4 and 12 months | Change in hemodynamic variables (mPAP, RAP, CI) from baseline to month 4 and month 12 as assessed by Right Heart Catheterization. |
| Secondary | Echocardiographic parameters | 4 and 12 months | Change in echocardiographic parameters (TAPSE, RV strain, Tei index, Left ventricular Eccentricity index, RV:LV area ratio) as assessed by Echocardiogram. |
| Secondary | RV function | 4 and 12 months | Change from baseline to month 4 in RV function as assessed by cardiac MRI. |
| Secondary | NT-PRo-BNP | 4 and 12 Months | Change from baseline NT-PRo-BNP value from baseline to month 4 and month 12 |
| Secondary | Exercise capacity | 4 and 12 months | Change from baseline to month 4 and month 12 in exercise capacity assessed by the 6 minute walk test |
| Secondary | Dyspnea | 4 and 12 months | Change from baseline to month 4 and month 12 in dyspnea as assessed by study questionnaire. |
| Secondary | Quality of Life Assessment | 4 and 12 months | Change from baseline to month 4 and month 12 in quality of life as assessed by study questionnaire. |
| Secondary | Functional Class | 4 and 12 months | Change from baseline to month 4 and month 12 in functional class as assessed by study questionnaire. |
| Secondary | Survival | 12 months | Survival at 12 months |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03809156
GET https://conductscience.org/api/trials/v1/NCT03809156/registered