Trial · NCT03818932

Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction

NCT03818932, Phase 2, Phase 3, Completed, Henry Ford Health System; results first posted 2026-03-19

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction. Trials, record NCT03818932. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03818932

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction
NCT number: NCT03818932
Status: Completed
Phases: Phase 2, Phase 3
Enrollment: 90 participants, actual
Lead sponsor: Henry Ford Health System
Conditions: Anterior Cruciate Ligament Injury
Interventions: Celecoxib, Hydrocodone-Acetaminophen, Ketorolac, Gabapentin, Acetaminophen, Diazepam
First posted: 2019-01-28
Last updated: 2026-03-19
Results first posted: 2026-03-19
Limitations and caveats: Patients were aware of the medicines they were taking, and knowledge of the treatment may have led to cognitive bias; however, data were recorded by a blinded observer with no knowledge of patient randomization in order to eliminate associated statistical bias.

Source ClinicalTrials.gov

Registered outcomes2

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Pain Levels Using the Visual Analog Scale	10 days post-operatively	Patients record pain levels using Visual analog scales for 10 days post-operatively. The visual analog scale is a validated measure for pain where 0 is no pain and 10 is the worst pain. Average daily pain was calculated for each patient. Higher values portend worse control.
Primary	Patient-Reported Outcomes Measurement Information System	From preoperative visit to 10 days post-operatively	Patient-Reported Outcomes Measurement Information System Physical Function (PROMIS PF) scores will be collected once preoperatively and at 10 days postoperatively. The PROMIS PF is scored on a 0-point to 100-point scale, with a population mean of 50 and SD of 10. 0 is equivalent to no physical function and 100 is equivalent to total physical function.

Source ClinicalTrials.gov

Outcomes2

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Pain Levels Using the Visual Analog Scale	10 days post-operatively		score on a scale (0-10 on VAS pain scale	MEAN
PRIMARY	Patient-Reported Outcomes Measurement Information System	From preoperative visit to 10 days post-operatively		score on a scale	MEAN

Source ClinicalTrials.gov

Results by group4

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Pain Levels Using the Visual Analog Scale	Post-Operative Non Opioid Pain Protocol	2.5	95% Confidence Interval 2.29 to 2.71	score on a scale (0-10 on VAS pain scale
Pain Levels Using the Visual Analog Scale	Post-Operative Traditional Pain Protocol	4.06	95% Confidence Interval 3.85 to 4.27	score on a scale (0-10 on VAS pain scale
Patient-Reported Outcomes Measurement Information System	Post-Operative Non Opioid Pain Protocol	61.4	Standard Deviation 8.9	score on a scale
Patient-Reported Outcomes Measurement Information System	Post-Operative Traditional Pain Protocol	66.3	Standard Deviation 8.2	score on a scale

Source ClinicalTrials.gov

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Post-Operative Non Opioid Pain Protocol	45
Overall Study	STARTED	Post-Operative Traditional Pain Protocol	45
Overall Study	COMPLETED	Post-Operative Non Opioid Pain Protocol	28
Overall Study	COMPLETED	Post-Operative Traditional Pain Protocol	34
Overall Study	NOT COMPLETED	Post-Operative Non Opioid Pain Protocol	17
Overall Study	NOT COMPLETED	Post-Operative Traditional Pain Protocol	11

Source ClinicalTrials.gov

Adverse events12

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk
other	Constipation	Gastrointestinal disorders	Post-Operative Non Opioid Pain Protocol	12	34
other	Constipation	Gastrointestinal disorders	Post-Operative Traditional Pain Protocol	13	28
other	Nausea	Gastrointestinal disorders	Post-Operative Non Opioid Pain Protocol	9	34
other	Nausea	Gastrointestinal disorders	Post-Operative Traditional Pain Protocol	10	28
other	Diarrhea	Gastrointestinal disorders	Post-Operative Non Opioid Pain Protocol	2	34
other	Diarrhea	Gastrointestinal disorders	Post-Operative Traditional Pain Protocol	2	28
other	Upset Stomach	Gastrointestinal disorders	Post-Operative Non Opioid Pain Protocol	8	34
other	Upset Stomach	Gastrointestinal disorders	Post-Operative Traditional Pain Protocol	9	28
other	Drowsy	Gastrointestinal disorders	Post-Operative Non Opioid Pain Protocol	18	34
other	Drowsy	Gastrointestinal disorders	Post-Operative Traditional Pain Protocol	12	28

1 to 10 of 12Source ClinicalTrials.gov

See all 12 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Post-Operative Non Opioid Pain Protocol	0	34
Total, all-cause mortality	Post-Operative Traditional Pain Protocol	0	28
Total, other adverse events	Post-Operative Non Opioid Pain Protocol	18	34
Total, other adverse events	Post-Operative Traditional Pain Protocol	13	28
Total, serious adverse events	Post-Operative Non Opioid Pain Protocol	0	34
Total, serious adverse events	Post-Operative Traditional Pain Protocol	0	28

Source ClinicalTrials.gov

Papers0

The papers the trial lists on ClinicalTrials.gov.

None in this release.

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Post-Operative Non Opioid Pain Protocol vs Post-Operative Traditional Pain Protocol: deaths from any cause	Trial comparisons
Post-Operative Non Opioid Pain Protocol vs Post-Operative Traditional Pain Protocol: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT03818932

GET https://conductscience.org/api/trials/v1/NCT03818932/registered

API reference For AI assistants