Trial · NCT03837470
Evaluation of Renal Sodium Excretion After Salt Loading in Heart Failure With Preserved Ejection Fraction
NCT03837470, Early phase 1, Completed, Adhish Agarwal
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Evaluation of Renal Sodium Excretion After Salt Loading in Heart Failure With Preserved Ejection Fraction. Trials, record NCT03837470. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03837470
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Evaluation of Renal Sodium Excretion After Salt Loading in Heart Failure With Preserved Ejection Fraction
- NCT number
- NCT03837470
- Status
- Completed
- Phases
- Early phase 1
- Enrollment
- 14 participants, actual
- Lead sponsor
- Adhish Agarwal
- Conditions
- Heart Failure With Preserved Ejection Fraction
- Interventions
- 0.9% Sodium Chloride, Furosemide 40 mg
- First posted
- 2019-02-12
- Last updated
- 2021-04-19
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Urinary Sodium Excretion | 5 Hours | Amount of sodium excretion following saline loading and diuretic challenge will be compared between HFpEF patients and controls |
| Primary | Urine Volume | 5 Hours | Volume of urine collected following saline loading and diuretic challenge will be compared between HFpEF patients and controls |
| Secondary | Change in NT-proBNP | 5 Hours | Average change in NT-proBNP values before and after saline loading and diuretic challenge will be compared between HFpEF patients and controls |
| Secondary | Serum Aldosterone | 5 Hours | Serum Aldosterone levels at baseline, after saline loading and after furosemide administration compared between HFpEF patients and controls |
| Secondary | Plasma Renin Activity | 5 Hours | Plasma renin activity levels at baseline, after saline loading and after furosemide administration compared between HFpEF patients and controls |
| Secondary | Plasma Nor-epinephrine | 5 Hours | Plasma nor-epinephrine levels at baseline, after saline loading and after furosemide administration compared between HFpEF patients and controls |
| Other | Urinary Exosomes | 5 Hours | Sodium transporters in Urinary exosomes will be characterized and compared between HFpEF patients and controls |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers24
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03837470
GET https://conductscience.org/api/trials/v1/NCT03837470/papers?page=2