Trial · NCT03843463
Escitalopram and Language Intervention for Subacute Aphasia
NCT03843463, Phase 2, Recruiting, Johns Hopkins University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Escitalopram and Language Intervention for Subacute Aphasia. Trials, record NCT03843463. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03843463
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Escitalopram and Language Intervention for Subacute Aphasia
- NCT number
- NCT03843463
- Status
- Recruiting
- Phases
- Phase 2
- Enrollment
- 88 participants, estimated
- Lead sponsor
- Johns Hopkins University
- Conditions
- Aphasia, Stroke
- Interventions
- Escitalopram 10mg, Placebo, Computer-delivered naming treatment
- First posted
- 2019-02-18
- Last updated
- 2026-09-03
Source ClinicalTrials.gov
Registered outcomes14
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Philadelphia Naming Test short-form accuracy score | Baseline, 1 week after computer-delivered naming treatment | Number of correctly named items of 30 total items on the computerized picture naming assessment. Scores ranges from 0 to 30 with higher scores meaning better naming ability. |
| Secondary | Language production as assessed by lexical features of discourse in "Cookie Theft" picture description | Baseline, 5 weeks after computer-delivered naming treatment | Lexical features, meaning carrying units of language (morphemes), will be counted for each Cookie Theft picture description. There is no maximum number of meaning carrying units, but norms are available to assist in the interpretation of this performance. |
| Secondary | Language production as assessed by content units included in picture description of "Cookie Theft" | Baseline, 5 weeks after computer-delivered naming treatment | Content units are based on a standard scoring template of commonly identified concepts (nouns and verbs) in the left and right regions of the "Cookie Theft" picture. Participants either include or fail to include 30 concepts on the left side of the picture and 23 concepts on the right side of the picture. A ratio of included left content units to included right content units then can be calculated and interpreted as a measure of hemispatial attention. |
| Secondary | Language production as assessed by rate of syllables per content unit produced in "Cookie Theft" picture description | Baseline, 5 weeks after computer-delivered naming treatment | Syllables included in the picture description are counted. Content units are based on a standard scoring template of commonly identified concepts (nouns and verbs) in the left and right regions of the "Cookie Theft" picture. Participants either include or fail to include 30 concepts on the left side of the picture and 23 concepts on the right side of the picture. The average rate of syllables per content unit produced can then be calculated and interpreted as a measure of efficiency in producing relevant information in the task. |
| Secondary | Depression as assessed by Patient Health Questionnaire (PHQ-9) | Baseline, 1 week after computer-delivered naming treatment | 9 item scale scored 0-3 for each item. PHQ-9 scores of 5, 10, 15, and 20 represent mild, moderate, moderately severe, and severe depression. PHQ-9 \>15 or suicidal ideation suggest depression sufficient for exclusion or removal from study. |
| Secondary | Language production as assessed by Morphosyntactic Generation (MorGen) Test | Baseline, 1 week after computer-delivered naming treatment | 60 item assessment of word morphology (e.g., plurals, possessives) and modifiers (e.g., number, size, color). Each item is scored based on produced accurate descriptors of an image relative to a second reference image (e.g., patients see two trees, one larger than the other, and the phrase "little tree" is elicited). Patients are scored for objects correctly named (nouns) out of 60, instances of correct use of plural marker out of 31, instances of correct use of numbers out of 8, instances of correct modifiers denoting size out of 16, instances of correct modifiers denoting color out of 19, instances of correct modifiers denoting possessive markers out of 17, and instances of correctly named possessing individuals (proper names provided on screen) out of 17. These scores can then be interpreted separately or averaged to interpret a broad morphosyntactic accuracy score. |
| Secondary | Stroke severity as assessed by NIH Stroke Scale (NIHSS) | Baseline, 5 weeks after computer-delivered naming treatment, 20 weeks after computer-delivered naming treatment | The NIHSS is a 15-item neurologic examination stroke scale used to evaluate the effect of acute cerebral infarction on the levels of consciousness, language, neglect, visual-field loss, extraocular movement, motor strength, ataxia, dysarthria, and sensory loss. A trained observer rates the patient's ability to answer questions and perform activities. Ratings for each item are scored with 3 to 5 grades with 0 as normal, and there is an allowance for untestable items. |
| Secondary | Post-stroke level of disability as assessed by modified Rankin Scale (mRS) | Baseline, 1 week after computer-delivered naming treatment | The mRS is a 6-level scale from "0-No symptoms" to "6-dead" used to evaluate the degree of disability in patients who have suffered a stroke. |
| Secondary | Stroke paresis severity as assessed by right hand strength | Baseline, 1 week after computer-delivered naming treatment | Right hand strength assessment by dynamometer |
| Secondary | Stroke paresis severity as assessed by right hand dexterity | Baseline, 1 week after computer-delivered naming treatment | Right hand dexterity assessment by 9 peg board test |
1 to 10 of 14Source ClinicalTrials.gov
See all 14 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers26
The papers the trial lists on ClinicalTrials.gov.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| P50DC014664 | Center for the Study of Aphasia Recovery (C-STAR) | FRIDRIKSSON, JULIUS | UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA | NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS | 2016 to 2025 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests1
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as |
|---|---|
| Picture Naming Test | Primary outcome |
Source ConductCognition
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03843463
GET https://conductscience.org/api/trials/v1/NCT03843463/papers?page=2