Trial · NCT03848728

Strategic Antiretroviral Therapy and HIV Testing for Youth in Rural Africa

NCT03848728, Not applicable, Completed, University of California, San Francisco; results first posted 2024-10-23

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Strategic Antiretroviral Therapy and HIV Testing for Youth in Rural Africa. Trials, record NCT03848728. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03848728

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Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Strategic Antiretroviral Therapy and HIV Testing for Youth in Rural Africa
NCT number: NCT03848728
Status: Completed
Phases: Not applicable
Enrollment: 1,988 participants, actual
Lead sponsor: University of California, San Francisco
Conditions: HIV
Interventions: SEARCH Youth combination intervention
First posted: 2019-02-21
Last updated: 2024-10-23
Results first posted: 2024-10-23

Source ClinicalTrials.gov

Registered outcomes1

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Effectiveness of SEARCH Youth Intervention	2 years	Percentage of study participants with virologic suppression (HIV RNA \<400 c/mL) at 2 years of follow-up. Mean was calculated as the average percentage across the clusters (clinics)

Source ClinicalTrials.gov

Outcomes1

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Effectiveness of SEARCH Youth Intervention	2 years	Study participants at year 2, excluding those who enrolled on/after Dec 1, 2019, transferred care, outmigrated, or withdrew.	% of participants	MEAN

Source ClinicalTrials.gov

Results by group8

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Category	Value	Spread	Units
Effectiveness of SEARCH Youth Intervention	Intervention Clinics	All	88.2	95% Confidence Interval 84.8 to 91.7	% of participants
Effectiveness of SEARCH Youth Intervention	Control Clinics	All	80.5	95% Confidence Interval 76.9 to 84.1	% of participants
Effectiveness of SEARCH Youth Intervention	Intervention Clinics	Engaged	90.9	95% Confidence Interval 87.7 to 94.0	% of participants
Effectiveness of SEARCH Youth Intervention	Control Clinics	Engaged	85.3	95% Confidence Interval 81.0 to 89.5	% of participants
Effectiveness of SEARCH Youth Intervention	Intervention Clinics	Recently engaged	80.1	95% Confidence Interval 72.7 to 87.5	% of participants
Effectiveness of SEARCH Youth Intervention	Control Clinics	Recently engaged	73.5	95% Confidence Interval 67.1 to 79.8	% of participants
Effectiveness of SEARCH Youth Intervention	Intervention Clinics	Re-engaging	84.8	95% Confidence Interval 72.7 to 97.0	% of participants
Effectiveness of SEARCH Youth Intervention	Control Clinics	Re-engaging	53.2	95% Confidence Interval 29.5 to 76.9	% of participants

Source ClinicalTrials.gov

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants	Units counted
Overall Study	STARTED	Intervention Clinics	1,012	14
Overall Study	STARTED	Control Clinics	976	14
Overall Study	COMPLETED	Intervention Clinics	865	14
Overall Study	COMPLETED	Control Clinics	809	14
Overall Study	NOT COMPLETED	Intervention Clinics	147	0
Overall Study	NOT COMPLETED	Control Clinics	167	0

Source ClinicalTrials.gov

Adverse events74

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
serious	Dehydration	Metabolism and nutrition disorders	Intervention Clinics	1	1,012	1
serious	Dehydration	Metabolism and nutrition disorders	Control Clinics	0	0	0
serious	Urinary tract infection	Infections and infestations	Intervention Clinics	1	1,012	1
serious	Urinary tract infection	Infections and infestations	Control Clinics	0	0	0
serious	Hernia	Gastrointestinal disorders	Intervention Clinics	1	1,012	1
serious	Hernia	Gastrointestinal disorders	Control Clinics	0	0	0
serious	Malaria	Infections and infestations	Intervention Clinics	4	1,012	4
serious	Malaria	Infections and infestations	Control Clinics	0	0	0
serious	Depression	Psychiatric disorders	Intervention Clinics	1	1,012	1
serious	Depression	Psychiatric disorders	Control Clinics	0	0	0

1 to 10 of 74Source ClinicalTrials.gov

See all 74 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Intervention Clinics	16	1,012
Total, all-cause mortality	Control Clinics	13	976
Total, other adverse events	Intervention Clinics	0	0
Total, other adverse events	Control Clinics	0	0
Total, serious adverse events	Intervention Clinics	48	1,012
Total, serious adverse events	Control Clinics	13	976

Source ClinicalTrials.gov

Papers9

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
19282780	BACKGROUND	PubMed
19298993	BACKGROUND	PubMed
23373540	BACKGROUND	PubMed
24076661	BACKGROUND	PubMed
25695494	BACKGROUND	PubMed
28102610	BACKGROUND	PubMed
35578398	DERIVED	PubMed
35818888	DERIVED	PubMed
37541706	DERIVED	PubMed

Grants2

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

Project	Title	Principal investigators	Organization	Funder	Fiscal years	Source
UH3HD096915	Strategic antiretroviral therapy and HIV testing for youth in rural Africa	HAVLIR, DIANE V	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT	2020 to 2022	NIH RePORTER
UG3HD096915	Strategic antiretroviral therapy and HIV testing for youth in rural Africa (SATURN)	HAVLIR, DIANE V	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT	2018 to 2019	NIH RePORTER

Trial comparisons2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Intervention Clinics vs Control Clinics: deaths from any cause	Trial comparisons
Intervention Clinics vs Control Clinics: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT03848728

GET https://conductscience.org/api/trials/v1/NCT03848728/events?page=2

API reference For AI assistants