Trial · NCT03877562
The Effect of CORT118335 on Olanzapine-Induced Weight Gain
NCT03877562, Phase 1, Completed, Corcept Therapeutics
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Effect of CORT118335 on Olanzapine-Induced Weight Gain. Trials, record NCT03877562. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03877562
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Effect of CORT118335 on Olanzapine-Induced Weight Gain
- NCT number
- NCT03877562
- Status
- Completed
- Phases
- Phase 1
- Enrollment
- 96 participants, actual
- Lead sponsor
- Corcept Therapeutics
- Conditions
- Antipsychotic-induced Weight Gain
- Interventions
- Olanzapine, CORT118335, Placebo
- First posted
- 2019-03-15
- Last updated
- 2020-04-28
- Other registries' IDs
- eudract:2019-000633-39
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Mean Change from Baseline in Body Weight | Pre-dose on Day 1 (Baseline) and Day 15 | |
| Secondary | Percentage of Participants with One or More Adverse Events | Up to Day 28 | |
| Secondary | Percentage of Participants with One or More Serious Adverse Events | Up to Day 28 | |
| Secondary | Percentage of Participants Discontinued from the Study due to an Adverse Event | Up to Day 28 | |
| Secondary | Mean Change from Baseline in Glucose | Pre-dose on Day 1 (Baseline), pre-dose on Days 8, 15, and 28 | |
| Secondary | Mean Change from Baseline in Insulin | Pre-dose on Day 1 (Baseline), pre-dose on Days 8, 15, and 28 | |
| Secondary | Mean Change from Baseline in Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) | Pre-dose on Day 1 (Baseline), pre-dose on Days 8, 15, and 28 | |
| Secondary | Mean Change from Baseline in Triglycerides | Pre-dose on Day 1 (Baseline), pre-dose on Days 8, 15, and 28 | |
| Secondary | Mean Change from Baseline in Waist-to-Hip Ratio | Pre-dose on Day 1 (Baseline), Days 8, 15, and 28 | |
| Secondary | Plasma Pharmacokinetics (PK) of CORT118335: Time from Dosing at which Maximum Concentration is Apparent (tmax) | Pre-dose and at pre-specified time points up to 24 hours after dosing on Day 7 |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03877562
GET https://conductscience.org/api/trials/v1/NCT03877562/registered