Trial · NCT03878030
Effect of Nusinersen on Adults With Spinal Muscular Atrophy
NCT03878030, Completed, Northwell Health
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effect of Nusinersen on Adults With Spinal Muscular Atrophy. Trials, record NCT03878030. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03878030
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effect of Nusinersen on Adults With Spinal Muscular Atrophy
- NCT number
- NCT03878030
- Status
- Completed
- Enrollment
- 12 participants, actual
- Lead sponsor
- Northwell Health
- Conditions
- Adult Spinal Muscular Atrophy
- Interventions
- nusinersen
- First posted
- 2019-03-18
- Last updated
- 2023-03-20
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in quantitative motor function | Two years | Primary Endpoint: Change from baseline to end of study in quantitative motor strength by dynamometry of upper limb muscles - shoulder abduction and elbow flexion/extension. |
| Primary | Change in upper limb motor function | Two years | Change from baseline to end of study in upper limb module score |
| Primary | Change in 6 minute walk test in ambulatory patients | Two years | Change in 6 minute walk test from baseline to end of study |
| Secondary | Change in pulmonary function by spirometry forced vital capacity (FVC) | Two years | Change in FVC from baseline to end of study |
| Secondary | Change in 10 meter walk test in ambulatory patients | Two years | Change from baseline to end of study in the 10 meter walk test |
| Secondary | Change in compound muscle action potential (CMAP) amplitude by nerve conduction velocity (NCV) criteria | Two years | Change from baseline to end of study in CMAP amplitude of responses from median, ulnar and peroneal motor nerves |
| Secondary | Change in pulmonary function by spirometry forced expiratory volume (FEV) | Two years | Change from baseline to end of study in FEV |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03878030
GET https://conductscience.org/api/trials/v1/NCT03878030/registered