Trial · NCT03887169
Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.
NCT03887169, Phase 1, Phase 2, Completed, Assistance Publique - Hôpitaux de Paris
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene. Trials, record NCT03887169. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03887169
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.
- NCT number
- NCT03887169
- Status
- Completed
- Phases
- Phase 1, Phase 2
- Enrollment
- 3 participants, actual
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Conditions
- Pulmonary Alveolar Proteinosis, Mutation Ala393Thr of the MARS Gene, mutationSer567Leu of the MARS Gene
- Interventions
- Methionine, Vitamin B12, B9, B6, C supplementation, Methionine/homocysteine Dosage, Thoracic CT scan, Abdominal and liver ultrasound., Brain MRI
- First posted
- 2019-03-22
- Last updated
- 2025-11-20
- Other registries' IDs
- eudract:2018-004140-28
Source ClinicalTrials.gov
Registered outcomes17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Tolerance Assessment | From day 0 to day 75 | No adverse event from day 0 to day 75. |
| Secondary | Respiratory rate (cycles /min) | At day 0, day 15, day 30, day 45, day 60, day 75 | number of cycles per minute |
| Secondary | Oxygen need (L/min) | At day 0, day 15, day 30, day 45, day 60, day 75 | Flow in L/min |
| Secondary | Respiratory signs of struggle | At day 0, day 15, day 30, day 45, day 60, day 75 | Presence or absence of signs |
| Secondary | Lung lesions | At Day 60 | Lesions appearance on thoracic CT scan, scored form 0 to 4 |
| Secondary | Lipo-proteinaceous material | At each bronchial-alveolar washes during the 2,5 months | Fluid examination |
| Secondary | Weight | At Day 15, Day 30, Day 45, Day 60, Day 75 | To evaluate Nutritional status |
| Secondary | mid upper arm circumference / head circumference rapport | At Day 15, Day 30, Day 45, Day 60, Day 75 | To evaluate Nutritional status |
| Secondary | Hepatomegaly | At Day 0, Day 15, Day 30, Day 45, Day 60, Day 75 | liver damage evaluate by physician during clinical examination |
| Secondary | cholestasis and hepatic cytolysis | At Day 0, Day 15, Day 30, Day 60, Day 75 | liver damage evaluate by biological parameters : ASAT, ALAT, GGT, PAL, Bilirubin |
1 to 10 of 17Source ClinicalTrials.gov
See all 17 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 34503986 | RESULT |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03887169
GET https://conductscience.org/api/trials/v1/NCT03887169/registered