Trial · NCT03892772
Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep Apnea
NCT03892772, Phase 1, Phase 2, Completed, Brigham and Women's Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep Apnea. Trials, record NCT03892772. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03892772
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep Apnea
- NCT number
- NCT03892772
- Status
- Completed
- Phases
- Phase 1, Phase 2
- Enrollment
- 23 participants, actual
- Lead sponsor
- Brigham and Women's Hospital
- Conditions
- Sleep Apnea
- Interventions
- SAS0421a, SAS0421b, SAS0421c, placebo
- First posted
- 2019-03-27
- Last updated
- 2022-03-02
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Apnea-hypopnea index [AHI] | 3 days | Apneas and hypopneas per hour (3% desat and/or arousal), % change from baseline |
| Secondary | Hypoxic Burden | 3 days | Desaturation area under curve × event frequency |
| Secondary | Arousal Index | 3 days | Number of arousals per hour (\>=3-sec), % change from baseline |
| Secondary | Visual Analog Scale for Sleep Quality | 3 days | Sleep Quality 0-10 scale, 0 worst sleep quality, 10 best sleep quality |
| Secondary | Visual Analog Scale for Waking Unrefreshed | 3 days | Waking Unrefreshed 0-10 scale, 0 extremely refreshed, 10 extremely unrefreshed |
| Other | Visual Analog Scale for Excessive Fatigue | 3 days | Excessive Fatigue 0-10 scale, 0 no fatigue, 10 highly fatigued |
| Other | Visual Analog Scale for Low Energy | 3 days | Low Energy 0-10 scale, 0 no trouble with energy, 10 extremely low energy |
| Other | Visual Analog Scale for Treatment Satisfaction | 3 days | Treatment Satisfaction 0-10 scale, 0 extremely dissatisfied, 10 extremely satisfied |
| Other | Proportion of Total Sleep Time in non-REM Stage 1 | 3 days | % Total sleep time |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03892772
GET https://conductscience.org/api/trials/v1/NCT03892772/registered