Trial · NCT03894683
Effect of Melatonin on Cardiovascular and Muscle Mass and Function in Patients With Heart Failure
NCT03894683, Phase 2, Unknown, Isfahan University of Medical Sciences
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effect of Melatonin on Cardiovascular and Muscle Mass and Function in Patients With Heart Failure. Trials, record NCT03894683. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03894683
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effect of Melatonin on Cardiovascular and Muscle Mass and Function in Patients With Heart Failure
- NCT number
- NCT03894683
- Status
- Unknown
- Phases
- Phase 2
- Enrollment
- 90 participants, estimated
- Lead sponsor
- Isfahan University of Medical Sciences
- Conditions
- Heart Failure With Reduced Ejection Fraction
- Interventions
- Melatonin 10 mg, Placebo Oral Tablet
- First posted
- 2019-03-28
- Last updated
- 2019-03-28
Source ClinicalTrials.gov
Registered outcomes21
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Composite clinical endpoint score | 6 months or earlier if patient was dropped out from the study | A score with the following components: all-cause mortality, hospitalization for heart failure during the study, and change in quality of life by Minnesota Living with Heart Failure Questionnaire (MLHFQ) |
| Secondary | Adverse effects of melatonin | Throughout the study up to 6 months | Adverse effects detected in the melatonin group compared with the placebo group |
| Secondary | Change in appendicular lean mass (kg) | Baseline and 6 months | Measured by dual-energy x-ray absorptiometry |
| Secondary | Change in lean body mass (kg) | Baseline and 3 months | Measured by bioimpedance analysis |
| Secondary | Change in lean body mass (kg) | Baseline and 6 months | Measured by bioimpedance analysis |
| Secondary | Change in grip strength (kg) | Baseline and 3 months | Measured by a hydraulic dynamometer |
| Secondary | Change in grip strength (kg) | Baseline and 6 months | Measured by a hydraulic dynamometer |
| Secondary | Change in exercise capacity | Baseline and 3 months | Measured by 6 minute walk test |
| Secondary | Change in exercise capacity | Baseline and 6 months | Measured by 6 minute walk test |
| Secondary | Change in Left ventricular ejection fraction (LVEF) | Baseline and 6 months | Measured by echocardiography using the Simpson method |
1 to 10 of 21Source ClinicalTrials.gov
See all 21 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03894683
GET https://conductscience.org/api/trials/v1/NCT03894683/registered?page=2