Trial · NCT03899324
Evaluation of the Efficacy and Safety of Bumetanide in Parkinson's Disease
NCT03899324, Phase 2, Unknown, B&A Therapeutics
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Evaluation of the Efficacy and Safety of Bumetanide in Parkinson's Disease. Trials, record NCT03899324. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03899324
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Evaluation of the Efficacy and Safety of Bumetanide in Parkinson's Disease
- NCT number
- NCT03899324
- Status
- Unknown
- Phases
- Phase 2
- Enrollment
- 40 participants, estimated
- Lead sponsor
- B&A Therapeutics
- Conditions
- Parkinson Disease
- Interventions
- Bumetanide white, oblong, scored tablet, Placebo white, oblong, scored tablet
- First posted
- 2019-04-02
- Last updated
- 2019-07-23
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | The primary endpoint of this study is the change from baseline (V2) to endpoint (V5) in the MDS-UPDRS III motor score, evaluated 1 hour after the intake of the study treatment (Bumetanide or placebo) in patients in the OFF state. | Between Day 1 and Day 120 | |
| Secondary | Change from V2 to V5 of the MDS-UPDRS part III and part I measured in a patient in the ON state. | Between Day 1 and Day 120 | Movement Disorder Society Unified Parkinson's Disease Rating Scale |
| Secondary | Change of scores of the MDS-UPDRS part II, III and IV during the trial, at D1 (V2), D30 (V3), D60 (V4) and D120 (V5). | Day 1, Day 30, Day 60, Day 120 | Movement Disorder Society Unified Parkinson's Disease Rating Scale |
| Secondary | Stand-Walk-Sit test at D1 (V2), D30 (V3), D60 (V4) and D120 (V5). | Day 1, Day 30, Day 60, Day 120 | |
| Secondary | Number of adverse events collected at each visit and phone calls. | Throughout the completion of the study, from Day 1 to Day 135 | |
| Other | Unified dyskinesia rating scale at D1 (V2), D30 (V3), D60 (V4) and D120 (V5). | Day 1, Day 30, Day 60, Day 120 | |
| Other | Awaken time spent in the OFF state, in the ON state with and without dyskinesia. | Between Day 0 (Screening) and Day 1 (V2), then between Day 60 (V4) and Day 120 (V5) | |
| Other | Patient's Clinical Global Impression (CGI) score at D1 (V2), D30 (V3), D60 (V4) and D120 (V5). | Day 1, Day 30, Day 60, Day 120 |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03899324
GET https://conductscience.org/api/trials/v1/NCT03899324/registered