Trial · NCT03915054
Amphiregulin Versus Non-Amphiregulin Supplementation to Maturation Culturing Medium in IVM.
NCT03915054, Not applicable, Completed, Mỹ Đức Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Amphiregulin Versus Non-Amphiregulin Supplementation to Maturation Culturing Medium in IVM. Trials, record NCT03915054. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03915054
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Amphiregulin Versus Non-Amphiregulin Supplementation to Maturation Culturing Medium in IVM.
- NCT number
- NCT03915054
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 30 participants, actual
- Lead sponsor
- Mỹ Đức Hospital
- Conditions
- PCOS, IVM
- Interventions
- AREG-TRIGGER, CONTROL-TRIGGER
- First posted
- 2019-04-16
- Last updated
- 2021-06-16
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Meiotic maturation efficiency | Two days after oocytes pick-up | Percentage of PB, GVBD, GV by the two types of trigger. The PB (or MII) oocyte displays the first PB in the PVS. GVBD oocytes have neither a visible GV nor PBI. GV oocyte presents an intracytoplasmic nucleus called the 'germinal vesicle'. |
| Primary | Number of transferable day 3 embryos | Five days after oocytes pick-up | Number of transferable day 3 embryos obtained by the two meiotic trigger types |
| Secondary | Ongoing pregnancy rate | At a minimum of 12 weeks from the beginning of the last menstrual cycle (each cycle is 4 weeks) up to the time of delivery | Pregnancy with detectable heart rate at 12 weeks' gestation up to the time of delivery |
| Secondary | Live birth rate | At least 24 weeks of gestation up to the time of delivery | Live birth is defined as the birth of at least one newborn after 24 weeks' gestation that exhibits any sign of life (twin will be a single count). For the timing of this occur, ongoing pregnancy will be used, i.e. ongoing pregnancy at 12 weeks will be used in calculations, conditional on the fact that this ongoing pregnancy results in live birth. |
| Secondary | Genetic and epigenetic analysis of cord blood of newborns (Will be done in a separate study) | 1 day (Prior to the initiation of IVF/IVM) and 1 day (at the time of delivery) | Newborn's material (cord blood) will be collected for genetics (karyotyping) and epigenetics analysis. |
| Secondary | Genetic and epigenetic analysis of cells from buccal smears of newborns (Will be done in a separate study) | 1 day (Prior to the initiation of IVF/IVM) and 1 day (at the time of delivery) | Newborn's material (cells from buccal smears) will be collected for genetics (karyotyping) and epigenetics analysis. |
| Secondary | Genetic and epigenetic analysis of placenta of newborns (Will be done in a separate study) | 1 day (Prior to the initiation of IVF/IVM) and 1 day (at the time of delivery) | Newborn's material (placenta) will be collected for genetics (karyotyping) and epigenetics analysis. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 34741172 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03915054
GET https://conductscience.org/api/trials/v1/NCT03915054/registered