Trial · NCT03918915
The Safety and Efficacy of SYD-101 in Children With Myopia
NCT03918915, Phase 3, Completed, Sydnexis, Inc.
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Safety and Efficacy of SYD-101 in Children With Myopia. Trials, record NCT03918915. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03918915
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Safety and Efficacy of SYD-101 in Children With Myopia
- NCT number
- NCT03918915
- Status
- Completed
- Phases
- Phase 3
- Enrollment
- 852 participants, actual
- Lead sponsor
- Sydnexis, Inc.
- Conditions
- Nearsightedness, Near Sightedness, Near-sightedness
- Interventions
- SYD-101 0.01%, SYD-101 0.03%, Vehicle
- First posted
- 2019-04-18
- Last updated
- 2026-07-30
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Myopic Progression <-0.75 D (Diopters) | Month 36 | Proportion of participants with confirmed myopic progression \<-0.75 D (diopters), based on SE (spherical equivalent) as measured by cycloplegic autorefraction |
| Secondary | Mean Annual Myopic Progression | Month 36 | Mean annual progression rate of myopia measured in diopters: Spherical Equivalent (SE) as measured by cycloplegic autorefraction. |
| Secondary | Proportion of Participants With Annual Myopia Progression Rate >=-0.50 D/Year | Through Month 36 | Proportion of participants with annual progression rate of myopia no worse than -0.50 D/year |
| Secondary | Proportion of Participants With Annual Myopia Progression Rate >=-0.25 D/Year | Through Month 36 | Proportion of participants with annual progression rate of myopia no worse than -0.25D/year |
| Secondary | Proportion of Participants With Increase of Myopia More Than -0.50 D | Month 36 | Proportion of participants with increase of myopia more than -0.50D |
| Secondary | Time to Progression of Myopia <-0.75 D (Diopters) | Up to 36 months (from date of randomization until date myopia progresses < -0.75 D) | Time (days) to confirmed myopic progression of worse than -0.75D. Time to Progression (days) 95% CI is calculated for the median. |
| Secondary | Mean Change From Baseline in Axial Length (Subset Only) | Baseline to Month 36 | Mean change from baseline in axial length at sites with requisite equipment |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 41870844 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03918915
GET https://conductscience.org/api/trials/v1/NCT03918915/registered