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Trial · NCT03948685

Registered outcomes27

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

ListOutcomeTime frameDescription
PrimaryThe Maximum NT-proBNP value change after Drug(Carvedilol SR or Placebo) administration.BaselineThe maximum NT-proBNP value change at baseline.
PrimaryThe Maximum NT-proBNP value change after Drug(Carvedilol SR or Placebo) administration.8 weeksThe maximum NT-proBNP value change from baseline to 8 weeks.
PrimaryThe Maximum NT-proBNP value change after Drug(Carvedilol SR or Placebo) administration.24 weeksThe maximum NT-proBNP value change from baseline to End of trial(24weeks).
Secondary
The changes of maximum surrogate markers values(hsTn, hsCRP, sST2, Galectine-3, IGFBP7, Neprilysin, D-dimer, MMP-2, Cystatin C, NAG, NGAL, KIM-1, BUN, Creatinine, Chloride, Na, K, PICP and spondin-1) after Drug(Carvedilol SR or Placebo) administration.
Baselinethe change of surrogate markers(hsTn, hsCRP etc) at baseline.
Secondary
The changes of maximum surrogate markers values(hsTn, hsCRP, sST2, Galectine-3, IGFBP7, Neprilysin, D-dimer, MMP-2, Cystatin C, NAG, NGAL, KIM-1, BUN, Creatinine, Chloride, Na, K, PICP and spondin-1) after Drug(Carvedilol SR or Placebo) administration.
8 weeksthe change of surrogate markers(hsTn, hsCRP etc) after 8 weeks.
Secondary
The changes of maximum surrogate markers values(hsTn, hsCRP, sST2, Galectine-3, IGFBP7, Neprilysin, D-dimer, MMP-2, Cystatin C, NAG, NGAL, KIM-1, BUN, Creatinine, Chloride, Na, K, PICP and spondin-1) after Drug(Carvedilol SR or Placebo) administration.
16 weeksthe change of surrogate markers(hsTn, hsCRP etc) after 16 weeks.
Secondary
The changes of maximum surrogate markers values(hsTn, hsCRP, sST2, Galectine-3, IGFBP7, Neprilysin, D-dimer, MMP-2, Cystatin C, NAG, NGAL, KIM-1, BUN, Creatinine, Chloride, Na, K, PICP and spondin-1) after Drug(Carvedilol SR or Placebo) administration.
24 weeksthe change of surrogate markers(hsTn, hsCRP etc) from baseline to end of trial(24 weeks)
SecondaryThe change in degree of dyspnea using VAS questionnaireBaselinethe change of dyspnea at baseline.
SecondaryThe change in degree of dyspnea using VAS questionnaire8 weeksthe change of dyspnea after 8 weeks.
SecondaryThe change in degree of dyspnea using VAS questionnaire16 weeksthe change of dyspnea after 16 weeks.
SecondaryThe change in degree of dyspnea using VAS questionnaire24 weeksthe change of dyspnea from baseline to end of trial(24 weeks)
Secondarythe change of body weightBaselinethe change of body weight at baseline.
Secondarythe change of body weight8 weeksthe change of body weight after 8 weeks.
Secondarythe change of body weight16 weeksthe change of body weight after 16 weeks.
Secondarythe change of body weight24 weeksthe change of body weight from baseline to end of trial(24 weeks)
Secondarythe frequency of symptomatic hypotension, symptomatic bradycardia and AV block above 2nd degreeBaselinethe frequency of symptomatic hypotension, symptomatic bradycardia and AV block above 2nd degree during the tiral
Secondarythe frequency of symptomatic hypotension, symptomatic bradycardia and AV block above 2nd degree8 weeksthe frequency of symptomatic hypotension, symptomatic bradycardia and AV block above 2nd degree during the tiral
Secondarythe frequency of symptomatic hypotension, symptomatic bradycardia and AV block above 2nd degree16 weeksthe frequency of symptomatic hypotension, symptomatic bradycardia and AV block above 2nd degree during the tiral
Secondarythe frequency of symptomatic hypotension, symptomatic bradycardia and AV block above 2nd degree24 weeksthe frequency of symptomatic hypotension, symptomatic bradycardia and AV block above 2nd degree during the tiral
Secondarythe frequency of hypo/hyperkalemia and worsening kidney functionBaselinethe frequency of hypo/hyperkalemia and worsening kidney function during the trial

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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