Trial · NCT03988335

A Study to Evaluate RIST4721 in Palmoplantar Pustulosis (PPP)

NCT03988335, Phase 2, Completed, Aristea Therapeutics, Inc.; results first posted 2022-03-03

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. A Study to Evaluate RIST4721 in Palmoplantar Pustulosis (PPP). Trials, record NCT03988335. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03988335

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: A Study to Evaluate RIST4721 in Palmoplantar Pustulosis (PPP)
NCT number: NCT03988335
Status: Completed
Phases: Phase 2
Enrollment: 35 participants, actual
Lead sponsor: Aristea Therapeutics, Inc.
Conditions: Palmoplantar Pustulosis
Interventions: RIST4721, Placebo
First posted: 2019-06-17
Last updated: 2022-04-05
Results first posted: 2022-03-03

Source ClinicalTrials.gov

Registered outcomes2

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Log Transformed Ratio of Postbaseline Fresh Pustule Count at Day 28 to Baseline	Baseline to Day 28	Relative change from baseline in fresh pustule count at Day 28
Primary	Log Transformed Ratio of Postbaseline Total Pustule Count at Day 28 to Baseline	Baseline to Day 28	Relative change from baseline in total pustule count at Day 28

Source ClinicalTrials.gov

Outcomes2

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Log Transformed Ratio of Postbaseline Fresh Pustule Count at Day 28 to Baseline	Baseline to Day 28		Log transformed ratio	MEAN
PRIMARY	Log Transformed Ratio of Postbaseline Total Pustule Count at Day 28 to Baseline	Baseline to Day 28		Log transformed ratio	MEAN

Source ClinicalTrials.gov

Results by group4

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Log Transformed Ratio of Postbaseline Fresh Pustule Count at Day 28 to Baseline	RIST4721 300 mg	0.86	Standard Deviation 0.692	Log transformed ratio
Log Transformed Ratio of Postbaseline Fresh Pustule Count at Day 28 to Baseline	Placebo	0.53	Standard Deviation 0.561	Log transformed ratio
Log Transformed Ratio of Postbaseline Total Pustule Count at Day 28 to Baseline	RIST4721 300 mg	0.99	Standard Deviation 0.667	Log transformed ratio
Log Transformed Ratio of Postbaseline Total Pustule Count at Day 28 to Baseline	Placebo	0.96	Standard Deviation 0.672	Log transformed ratio

Source ClinicalTrials.gov

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	RIST4721	16
Overall Study	STARTED	Placebo	19
Overall Study	COMPLETED	RIST4721	14
Overall Study	COMPLETED	Placebo	18
Overall Study	NOT COMPLETED	RIST4721	2
Overall Study	NOT COMPLETED	Placebo	1

Source ClinicalTrials.gov

Adverse events64

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	Fatigue	General disorders	RIST4721 300 mg	1	15	1
other	Fatigue	General disorders	Placebo	0	19	0
other	Anxiety	Psychiatric disorders	RIST4721 300 mg	1	15	1
other	Anxiety	Psychiatric disorders	Placebo	0	19	0
other	Vaginal haemorrhage	Reproductive system and breast disorders	RIST4721 300 mg	0	15	0
other	Vaginal haemorrhage	Reproductive system and breast disorders	Placebo	1	19	1
other	Procedural pain	Injury, poisoning and procedural complications	RIST4721 300 mg	2	15	2
other	Procedural pain	Injury, poisoning and procedural complications	Placebo	1	19	1
other	Ligament sprain	Injury, poisoning and procedural complications	RIST4721 300 mg	0	15	0
other	Ligament sprain	Injury, poisoning and procedural complications	Placebo	1	19	1

1 to 10 of 64Source ClinicalTrials.gov

See all 64 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	RIST4721 300 mg	0	15
Total, all-cause mortality	Placebo	0	19
Total, other adverse events	RIST4721 300 mg	13	15
Total, other adverse events	Placebo	7	19
Total, serious adverse events	RIST4721 300 mg	0	15
Total, serious adverse events	Placebo	0	19

Source ClinicalTrials.gov

Papers1

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as
34716902	DERIVED

Source PubMed

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
RIST4721 300 mg vs Placebo: deaths from any cause	Trial comparisons
RIST4721 300 mg vs Placebo: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT03988335

GET https://conductscience.org/api/trials/v1/NCT03988335/events?page=2

API reference For AI assistants