Trial · NCT03988374

Clinical Efficacy Evaluation of Three Dentifrices

NCT03988374, Phase 2, Completed, Church & Dwight Company, Inc.; results first posted 2021-08-23

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Clinical Efficacy Evaluation of Three Dentifrices. Trials, record NCT03988374. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03988374

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Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Clinical Efficacy Evaluation of Three Dentifrices
NCT number: NCT03988374
Status: Completed
Phases: Phase 2
Enrollment: 319 participants, actual
Lead sponsor: Church & Dwight Company, Inc.
Conditions: Gingival Inflammation and Bleeding, Dental Plaque
Interventions: Dentifrices
First posted: 2019-06-17
Last updated: 2021-08-23
Results first posted: 2021-08-23

Source ClinicalTrials.gov

Registered outcomes3

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Mean Within-Treatment Whole-Mouth Score - Gingival Efficacy	baseline, six weeks, 3 months and 6 months	Mean Within-Treatment Whole-Mouth Score as measured by Gingival Index (0=absence of inflammation, 1=mild inflammation: slight change in color, little change in texture of any portion of but not the entire marginal or papillary gingival unit, 2=mild inflammation: slight change in color, little change in texture to entire marginal or papillary gingival unit, 3=moderate inflammation: glazing, redness, edema and/or hypertrophy of the marginal or papillary gingival unit, 4=severe inflammation: marked redness, edema and/or hypertrophy of the marginal or papillary gingival unit, spontaneous bleeding, congestion, or ulceration. The scale ranges from 0-4.
Primary	Mean Within-Treatment Whole-Mouth Score - Gingival Bleeding Efficacy	baseline, six week, three months, and six months	Mean Within-Treatment Whole-Mouth Score as measured by Gingival Bleeding Index (0=absence of bleeding after 30 seconds, 1= bleeding observed after 30 seconds, 2= bleeding occurs instantly). The scale ranges from 0-2.
Primary	Mean Within-Treatment Whole-Mouth Score - Plaque Efficacy	baseline, six weeks, three months, and six months	Mean Within-Treatment Whole-Mouth Score as measured by Plaque Index (0=no visible plaque, 1=separate flecks of plaque at the cervical margin of the tooth, 2=a thin, continuous band of plaque (up to 1mm wide) at the cervical margin, 3= a band of plaque wider than 1 mm but covering less than one-third of the crown, 4=plaque covering at least one-third but less than two-thirds of the crown, 5= plaque covering two-thirds or more of the crown). The scale ranges from 0-5.

Source ClinicalTrials.gov

Outcomes3

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as
PRIMARY	Mean Within-Treatment Whole-Mouth Score - Gingival Efficacy	baseline, six weeks, 3 months and 6 months	units on a scale	MEAN
PRIMARY	Mean Within-Treatment Whole-Mouth Score - Gingival Bleeding Efficacy	baseline, six week, three months, and six months	units on a scale	MEAN
PRIMARY	Mean Within-Treatment Whole-Mouth Score - Plaque Efficacy	baseline, six weeks, three months, and six months	units on a scale	MEAN

Source ClinicalTrials.gov

Results by group36

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Category	Value	Spread	Units
Mean Within-Treatment Whole-Mouth Score - Gingival Efficacy	0% Baking Soda Dentifrice	Baseline	2.081	Standard Deviation 0.096	units on a scale
Mean Within-Treatment Whole-Mouth Score - Gingival Efficacy	20% Baking Soda Dentifrice	Baseline	2.094	Standard Deviation 0.117	units on a scale
Mean Within-Treatment Whole-Mouth Score - Gingival Efficacy	35% Baking Soda Dentifrice	Baseline	2.092	Standard Deviation 0.106	units on a scale
Mean Within-Treatment Whole-Mouth Score - Gingival Efficacy	0% Baking Soda Dentifrice	6 weeks	1.996	Standard Deviation 0.138	units on a scale
Mean Within-Treatment Whole-Mouth Score - Gingival Efficacy	20% Baking Soda Dentifrice	6 weeks	1.919	Standard Deviation 0.171	units on a scale
Mean Within-Treatment Whole-Mouth Score - Gingival Efficacy	35% Baking Soda Dentifrice	6 weeks	1.882	Standard Deviation 0.174	units on a scale
Mean Within-Treatment Whole-Mouth Score - Gingival Efficacy	0% Baking Soda Dentifrice	3 months	1.980	Standard Deviation 0.155	units on a scale
Mean Within-Treatment Whole-Mouth Score - Gingival Efficacy	20% Baking Soda Dentifrice	3 months	1.841	Standard Deviation 0.198	units on a scale
Mean Within-Treatment Whole-Mouth Score - Gingival Efficacy	35% Baking Soda Dentifrice	3 months	1.766	Standard Deviation 0.229	units on a scale
Mean Within-Treatment Whole-Mouth Score - Gingival Efficacy	0% Baking Soda Dentifrice	6 months	1.946	Standard Deviation 0.149	units on a scale

1 to 10 of 36Source ClinicalTrials.gov

See all 36 results by group

Participant flow9

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	0% Baking Soda Dentifrice	104
Overall Study	STARTED	20% Baking Soda Dentifrice	107
Overall Study	STARTED	35% Baking Soda Dentifrice	108
Overall Study	COMPLETED	0% Baking Soda Dentifrice	103
Overall Study	COMPLETED	20% Baking Soda Dentifrice	105
Overall Study	COMPLETED	35% Baking Soda Dentifrice	107
Overall Study	NOT COMPLETED	0% Baking Soda Dentifrice	1
Overall Study	NOT COMPLETED	20% Baking Soda Dentifrice	2
Overall Study	NOT COMPLETED	35% Baking Soda Dentifrice	1

Source ClinicalTrials.gov

Adverse events12

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	Primary discomforts	General disorders	0% Baking Soda Dentifrice	1	103	1
other	Primary discomforts	General disorders	20% Baking Soda Dentifrice	11	105	11
other	Primary discomforts	General disorders	35% Baking Soda Dentifrice	0	107	0
other	Primary discomforts	General disorders	0% Baking Soda Dentifrice	3	103	3
other	Primary discomforts	General disorders	20% Baking Soda Dentifrice	1	105	1
other	Primary discomforts	General disorders	35% Baking Soda Dentifrice	0	107	0
other	Primary discomforts	General disorders	0% Baking Soda Dentifrice	0	103	0
other	Primary discomforts	General disorders	20% Baking Soda Dentifrice	2	105	2
other	Primary discomforts	General disorders	35% Baking Soda Dentifrice	0	107	0
other	Primary discomforts	General disorders	0% Baking Soda Dentifrice	0	103	0

1 to 10 of 12Source ClinicalTrials.gov

See all 12 adverse events

Adverse event totals9

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	0% Baking Soda Dentifrice	0	103
Total, all-cause mortality	20% Baking Soda Dentifrice	0	105
Total, all-cause mortality	35% Baking Soda Dentifrice	0	107
Total, other adverse events	0% Baking Soda Dentifrice	4	103
Total, other adverse events	20% Baking Soda Dentifrice	17	105
Total, other adverse events	35% Baking Soda Dentifrice	2	107
Total, serious adverse events	0% Baking Soda Dentifrice	0	103
Total, serious adverse events	20% Baking Soda Dentifrice	0	105
Total, serious adverse events	35% Baking Soda Dentifrice	0	107

Source ClinicalTrials.gov

Papers0

The papers the trial lists on ClinicalTrials.gov.

None in this release.

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons0

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

None in this release.

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT03988374

GET https://conductscience.org/api/trials/v1/NCT03988374/results?page=2

API reference For AI assistants