Trial · NCT03998163
CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus
NCT03998163, Phase 3, Completed, Cara Therapeutics, Inc.; results first posted 2021-10-15
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus. Trials, record NCT03998163. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03998163
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus
- NCT number
- NCT03998163
- Status
- Completed
- Phases
- Phase 3
- Enrollment
- 222 participants, actual
- Lead sponsor
- Cara Therapeutics, Inc.
- Conditions
- Uremic Pruritus
- Interventions
- CR845 0.5 mcg/kg
- First posted
- 2019-06-26
- Last updated
- 2021-10-15
- Results first posted
- 2021-10-15
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of Participants With AEs. | Up to Follow-Up Visit (Week 13-14) | Assessed by monitoring of adverse events. |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Number of Participants With AEs. | Up to Follow-Up Visit (Week 13-14) | Participants | COUNT_OF_PARTICIPANTS |
Source ClinicalTrials.gov
Results by group1
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Number of Participants With AEs. | CR845 0.5mcg/kg | 143 | Participants |
Source ClinicalTrials.gov
Participant flow3
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | CR845 0.5mcg/kg | 222 | |
| Overall Study | COMPLETED | CR845 0.5mcg/kg | 197 | |
| Overall Study | NOT COMPLETED | CR845 0.5mcg/kg | 25 |
Source ClinicalTrials.gov
Adverse events66
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Diarrhoea | Gastrointestinal disorders | CR845 0.5mcg/kg | 11 | 222 | |
| serious | Anaemia | Blood and lymphatic system disorders | CR845 0.5mcg/kg | 2 | 222 | |
| serious | Cardio-respiratory arrest | Cardiac disorders | CR845 0.5mcg/kg | 2 | 222 | |
| serious | Acute myocardial infarction | Cardiac disorders | CR845 0.5mcg/kg | 1 | 222 | |
| serious | Angina pectoris | Cardiac disorders | CR845 0.5mcg/kg | 1 | 222 | |
| serious | Atrial flutter | Cardiac disorders | CR845 0.5mcg/kg | 1 | 222 | |
| serious | Chronic left ventricular failure | Cardiac disorders | CR845 0.5mcg/kg | 1 | 222 | |
| serious | Palpitations | Cardiac disorders | CR845 0.5mcg/kg | 1 | 222 | |
| serious | Primary adrenal insufficiency | Endocrine disorders | CR845 0.5mcg/kg | 1 | 222 | |
| serious | Gastrointestinal haemorrhage | Gastrointestinal disorders | CR845 0.5mcg/kg | 2 | 222 |
1 to 10 of 66Source ClinicalTrials.gov
See all 66 adverse eventsAdverse event totals3
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | CR845 0.5mcg/kg | 3 | 222 |
| Total, other adverse events | CR845 0.5mcg/kg | 11 | 222 |
| Total, serious adverse events | CR845 0.5mcg/kg | 45 | 222 |
Source ClinicalTrials.gov
Papers5
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03998163
GET https://conductscience.org/api/trials/v1/NCT03998163/events?page=2