Trial · NCT04055909
Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock
NCT04055909, Phase 2, Active not recruiting, Inotrem
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock. Trials, record NCT04055909. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04055909
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock
- NCT number
- NCT04055909
- Status
- Active not recruiting
- Phases
- Phase 2
- Enrollment
- 355 participants, actual
- Lead sponsor
- Inotrem
- Conditions
- Shock, Septic
- Interventions
- nangibotide low dose, nangibotide high dose, placebo
- First posted
- 2019-08-14
- Last updated
- 2023-04-11
- Other registries' IDs
- eudract:2018-004827-36
Source ClinicalTrials.gov
Registered outcomes15
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Sequential organ failure assessment (SOFA) score | day 5 | Change of total SOFA score from baseline to day 5 (in the subgroup defined by patients with elevated sTREM-1 baseline levels and in the overall population) |
| Secondary | All-cause mortality | day 5 and day 28 | all-cause mortality on D5 and D28 |
| Secondary | Duration of ICU stay | day 28 | hospitalization |
| Secondary | Organe support free survival | day 28 | time to organe support free |
| Secondary | Sepsis support index (SSI) | day 28 | Sepsis support index |
| Secondary | Daily change of total Sequential organ failure assessment (SOFA) score and individual subscores | day 1, day 2, day 3, day 4, day 5, day 6 and day 7 | Daily change of total SOFA score and individual subscores |
| Secondary | Duration of Vasopressor use | day 28 | Change in the Duration of Vasopressor use |
| Secondary | Duration of Invasive mechanical ventilation (IMV) | day 28 | Change in the Duration of Invasive mechanical ventilation (IMV) |
| Secondary | Duration of Renal support | day 28 | Change in the Duration of renal replacement therapy, RRT |
| Secondary | All-cause mortality | 12 months | all-cause mortality up to 12 months |
1 to 10 of 15Source ClinicalTrials.gov
See all 15 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04055909
GET https://conductscience.org/api/trials/v1/NCT04055909/registered