Trial · NCT04111666
A Phase 1 First in Human Study to Assess Safety and Tolerability of AL101
NCT04111666, Phase 1, Completed, Alector Inc.
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Phase 1 First in Human Study to Assess Safety and Tolerability of AL101. Trials, record NCT04111666. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04111666
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Phase 1 First in Human Study to Assess Safety and Tolerability of AL101
- NCT number
- NCT04111666
- Status
- Completed
- Phases
- Phase 1
- Enrollment
- 88 participants, actual
- Lead sponsor
- Alector Inc.
- Conditions
- Healthy
- Interventions
- AL101, Placebo
- First posted
- 2019-10-01
- Last updated
- 2022-08-10
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Evaluation of safety and tolerability of AL101 measured by number of subjects with adverse events and Dose Limiting Adverse Event (DLAEs) | either 57, 113, or 141 days, depending on the cohort | Incidence of adverse events and dose limiting Adverse Events during the DLAE observation period and/or study treatment periods. |
| Secondary | Pharmacokinetics (PK) of AL101 | either 57, 113, or 141 days, depending on the cohort | Serum and CSF concentration of AL101 at specified time points |
| Secondary | Maximum plasma concentration (Cmax) for AL101 | either 57, 113, or 141 days, depending on the cohort | Evaluate Cmax for serum and CSF concentration of AL101 at specified time points |
| Secondary | Area under the curve concentration (AUC) for AL101 | either 57, 113, or 141 days, depending on the cohort | Evaluate AUC for serum and CSF concentration of AL101 at specified time points |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 40713730 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04111666
GET https://conductscience.org/api/trials/v1/NCT04111666/registered