Trial · NCT04115020
Low Dose Naltrexone for Chronic Pain in Osteoarthritis and Inflammatory Arthritis
NCT04115020, Phase 2, Withdrawn, Brigham and Women's Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Low Dose Naltrexone for Chronic Pain in Osteoarthritis and Inflammatory Arthritis. Trials, record NCT04115020. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04115020
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Low Dose Naltrexone for Chronic Pain in Osteoarthritis and Inflammatory Arthritis
- NCT number
- NCT04115020
- Status
- Withdrawn
- Phases
- Phase 2
- Enrollment
- 0 participants, actual
- Lead sponsor
- Brigham and Women's Hospital
- Conditions
- Osteoarthritis, Arthritis, Rheumatoid, Arthritis, Psoriatic
- Interventions
- Naltrexone, Placebo
- First posted
- 2019-10-03
- Last updated
- 2020-01-09
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Brief Pain Inventory - Pain Interference | 16 weeks | Average of 7 questions on how much pain has interfered with general function, walking ability, mood, normal work, relations with other people, sleep, and enjoyment of life |
| Secondary | Brief Pain Inventory - Pain Severity | 16 weeks | Average severity of pain in the past 7 days (0-10) |
| Secondary | painDETECT | 16 weeks | Measure of neuropathic pain (0-38) |
| Secondary | Brief Fatigue Inventory | 16 weeks | Questionnaire, severity of fatigue and fatigue's interference with activity (0-10 scales). |
| Secondary | PROMIS-29 | 16 weeks | Questionnaire, survey of health-related quality of life across 8 domains. |
| Secondary | Beck Depression Inventory-II | 16 weeks | Questionnaire measuring severity of depression. Used primarily during screening to exclude enrollment of patients with severe depression, but also as a safety outcome measure during the study. |
| Secondary | Clinical Global Impression of Severity (CGI-S) | 16 weeks | 7-point scale of patients' self-reporting of severity during the study. |
| Secondary | Clinical Global Impression of Improvement (CGI-I) | 16 weeks | 7-point scale of patients' self-reporting of improvement or worsening during the study |
| Secondary | Pressure-pain threshold testing | 16 weeks | Measurement of minimum pressure needed to cause detectable pain at each knee |
| Secondary | DAS-28 | 16 weeks | Assessment of disease activity in rheumatoid arthritis (only for patients with rheumatoid arthritis) |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04115020
GET https://conductscience.org/api/trials/v1/NCT04115020/registered