Trial · NCT04140786
Optimizing IV Gentamicin in JEB
NCT04140786, Phase 1, Phase 2, Unknown, University of Southern California
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Optimizing IV Gentamicin in JEB. Trials, record NCT04140786. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04140786
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Optimizing IV Gentamicin in JEB
- NCT number
- NCT04140786
- Status
- Unknown
- Phases
- Phase 1, Phase 2
- Enrollment
- 6 participants, estimated
- Lead sponsor
- University of Southern California
- Conditions
- Junctional Epidermolysis Bullosa
- Interventions
- Gentamicin Sulfate, Injectable
- First posted
- 2019-10-28
- Last updated
- 2022-11-03
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Laminin 332 Expression in Skin | 3 months | Expression of laminin 332 as assessed by immunofluorescence of patient skin sections as a percentage of normal skin. |
| Primary | Safety (Ototoxicity) | 3 months | Testing for any gentamicin-associated auditory impairment as assessed by pure-tone audiometry assessments. |
| Primary | Safety (Nephrotoxicity) | 3 months | Testing for any gentamicin-associated renal impairment as assessed by calculated creatinine clearance. |
| Primary | Safety (Autoimmune Response) | 3 months | Testing for the presence of auto antibodies to newly formed laminin 332 in response to gentamicin as assessed by specific ELISA. |
| Secondary | Wound Healing | 3 months | Size of skin wounds selected for monitoring at baseline as assessed by computer assisted planimetry of photographs. |
| Secondary | Epidermolysis Bullosa Disease and Activity and Scarring Index (EBDASI) | 3 months | A disease scoring system designed for patients with epidermolysis bullosa (EB). |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 35234826 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04140786
GET https://conductscience.org/api/trials/v1/NCT04140786/registered