Trial · NCT04167163
Abaloparatide Before Total Knee Arthroplasty
NCT04167163, Phase 4, Completed, University of Wisconsin, Madison
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Abaloparatide Before Total Knee Arthroplasty. Trials, record NCT04167163. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04167163
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Abaloparatide Before Total Knee Arthroplasty
- NCT number
- NCT04167163
- Status
- Completed
- Phases
- Phase 4
- Enrollment
- 58 participants, actual
- Lead sponsor
- University of Wisconsin, Madison
- Conditions
- Osteoporosis, Arthroplasties, Knee Replacement
- Interventions
- Abaloparatide
- First posted
- 2019-11-18
- Last updated
- 2026-06-05
Source ClinicalTrials.gov
Registered outcomes13
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Distal Femoral Bone Mineral Density (BMD) at the 25% Regions of Interest (ROIs) | Baseline and approximately 18 months on study (15 months post-TKA) | Bone mineral density change at the 25% ROI of the surgical leg. Dual-energy X-ray absorptiometry (DXA) measured BMD was obtained at a point (ROI) 25% the length of the total surgical femur. Percent change at 25% ROI was calculated from baseline to 18 months. |
| Secondary | Change in Distal Femoral BMD at the 15% and 60% ROI | Baseline and approximately 18 months on study (15 months post-TKA) | Bone mineral density percent change at the 15% and 60% ROI of the surgical leg |
| Secondary | TBS Assessment by TRIP at the 15%, 25%, and 60% Femur ROIs | 18 months on study (15 months post-TKA) | Trabecular bone score (TBS) assessment by Texture Research Investigation (Platform (TRIP) software change at the 15% and 25% femur ROIs (TBS \>1.350 is normal; TBS between 1.200 and 1.350 is indicative of partially degraded microarchitecture; and TBS \<1.200 equals degraded microarchitecture). |
| Secondary | Knee Injury & Osteoarthritis Outcome Score (KOOS) JR | 18 months on study (15 months post-TKA) | Patient reported knee function score. The KOOS, JR was developed from the original long version of the Knee injury and Osteoarthritis Outcome Score (KOOS) survey using Rasch analysis. The KOOS, JR contains 7 items from the original KOOS survey. Items are coded from 0 to 4, none to extreme respectively. KOOS, JR is scored by summing the raw response (range 0-28) and then converting it to an interval score (0-100). The interval score ranges from 0 to 100 where 0 represents total knee disability and 100 represents perfect knee health. |
| Secondary | Change in Veterans RAND 12 (VR-12) Question Health Survey Score: Physical Health Component | Baseline and approximately 18 months on study (15 months post-TKA) | 12 Item Health Survey using patient's self assessment of their perspective of their health and ability to do daily functions. Scores are derived using an algorithm that is referenced to a metric centered at 50.0 where a zero score indicates the lowest level of health and 100 indicates the highest level of health. |
| Secondary | Change in Veterans RAND 12 (VR-12) Question Health Survey Score: Mental Health Component | Baseline and approximately 18 months on study (15 months post-TKA) | 12 Item Health Survey using patient's self assessment of their perspective of their health and ability to do daily functions. Scores are derived using an algorithm that is referenced to a metric centered at 50.0 where a zero score indicates the lowest level of health and 100 indicates the highest level of health. |
| Secondary | Forgotten Joint Survey(FJS) Score | 18 months on study (15 months post-TKA) | FJS-12 consists of 12 questions and is scored using a 5-point response format with the raw scores transformed onto a 0- to 100-point scale. High scores indicate good outcome, that is, a high degree of forgetting the joint in everyday life (forgotten joint phenomenon). |
| Secondary | Change in Body Composition Using Bioelectrical Impedance Analysis of Lean Mass | Baseline and approximately 18 months on study (15 months post-TKA) | Change in total body composition using bioelectrical impedance analysis of lean mass. |
| Secondary | Change in Body Composition Using Bioelectrical Impedance Analysis of Fat Mass. | Baseline and approximately 18 months on study (15 months post-TKA) | Change in total body composition using bioelectrical impedance analysis of fat mass. |
| Secondary | TKA Complications: Number of Participants Needed Revision Surgery | 18 months on study (15 months post-TKA) | TKA complications: Number of participants needed revision surgery |
1 to 10 of 13Source ClinicalTrials.gov
See all 13 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers43
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04167163
GET https://conductscience.org/api/trials/v1/NCT04167163/papers?page=2