Trial · NCT04177602
Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer - The Phase I/II TARC Trial
NCT04177602, Phase 1, Phase 2, Terminated, Universitätsklinikum Hamburg-Eppendorf
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer - The Phase I/II TARC Trial. Trials, record NCT04177602. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04177602
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer - The Phase I/II TARC Trial
- NCT number
- NCT04177602
- Status
- Terminated
- Phases
- Phase 1, Phase 2
- Enrollment
- 10 participants, actual
- Lead sponsor
- Universitätsklinikum Hamburg-Eppendorf
- Conditions
- Locally Advanced Rectal Cancer
- Interventions
- Trifluridine/tipiracil chemoradiation, Capecitabine based chemoradiation
- First posted
- 2019-11-26
- Last updated
- 2023-02-22
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Maximum tolerated dose (MTD)/Phase 1 part | 8 weeks | Toxicity |
| Primary | Rate of pathological complete remissions (pCR)/Phase 2 part | 3 months | Pathohistological response |
| Secondary | Disease free survival (DFS) | 4 years | recurrence and survival |
| Secondary | Overall survival (OS) | 4 years | Survival |
| Secondary | Loco-regional failure | 4 years | Loco-regional recurrence |
| Secondary | Histopathological R0 resection rate | 3 months | Pathohistological response |
| Secondary | Tumour regression grades | 3 months | Pathohistological response |
| Secondary | Pathological down-staging (ypT0-2N0) rate | 3 months | Pathohistological response |
| Secondary | Neoadjuvant rectal score (NAR) | 3 months | Clinical stage and Pathohistological response (\<8 low, 8-16 intermediate, \>16 high risk) |
| Secondary | Adverse event rate | 3 months | Rate of adverse events according to NCI CTC AE v5 |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04177602
GET https://conductscience.org/api/trials/v1/NCT04177602/registered