Using rTMS to Explore Neural Mechanisms of Stress-Induced Opioid Use
NCT04181515, Phase 2, Withdrawn, Wayne State University
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Using rTMS to Explore Neural Mechanisms of Stress-Induced Opioid Use | ClinicalTrials.gov |
| NCT number | NCT04181515 | ClinicalTrials.gov |
| Status | Withdrawn | ClinicalTrials.gov |
| Phases | Phase 2 | ClinicalTrials.gov |
| Enrollment | 0 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Wayne State University | ClinicalTrials.gov |
| Conditions | Stress, Opioid-use Disorder | ClinicalTrials.gov |
| Interventions | Placebo oral tablet, Yohimbine + Hydrocortisone, sham rTMS, active rTMS | ClinicalTrials.gov |
| First posted | 2019-11-29 | ClinicalTrials.gov |
| Last updated | 2023-04-13 | ClinicalTrials.gov |
Registered outcomes 19
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Addiction Stroop task | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | reaction time (msec) measure of cognitive interference | ClinicalTrials.gov |
| Primary | Digit Span Task | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | number of digits recalled, measure of verbal working memory | ClinicalTrials.gov |
| Primary | Wisconsin Card Sorting Task | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | number of correct items, measures ability to shift set and assesses cognitive flexibility | ClinicalTrials.gov |
| Primary | Monetary Incentive Delay task | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | number of rewards received, measure of motivation | ClinicalTrials.gov |
| Primary | Delay Discounting task | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | rate of monetary discounting | ClinicalTrials.gov |
| Primary | Drug/Money Choice Task | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | number of hypothetical choices between a constant amount of preferred opioid (relative to money) | ClinicalTrials.gov |
| Primary | Blood pressure | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | Systolic/diastolic BP (mm Hg) | ClinicalTrials.gov |
| Primary | Heart rate | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | Heart rate (beats/min) | ClinicalTrials.gov |
| Primary | Saliva cortisol level | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | Saliva cortisol level (µg/dL) | ClinicalTrials.gov |
| Primary | Saliva alpha-amylase level | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | Saliva alpha-amylase level (U/mL) | ClinicalTrials.gov |
| Primary | Serum prolactin level | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | Serum prolactin level (pg/dL) | ClinicalTrials.gov |
| Primary | Serum BDNF level | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | Serum brain derived neurotrophic factor level (pg/dL) | ClinicalTrials.gov |
| Primary | Positive and Negative Affect Schedule (PANAS) positive affect | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | 10-item sub scale score of positive affect | ClinicalTrials.gov |
| Primary | Positive and Negative Affect Schedule (PANAS) negative affect | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | 10-item sub scale score of negative affect | ClinicalTrials.gov |
| Primary | State Trait Anxiety Inventory | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | state anxiety scores | ClinicalTrials.gov |
| Primary | Desire for Drug Questionnaire | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | opioid craving score | ClinicalTrials.gov |
| Primary | Opiate-32 Questionnaire, Agonist score | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | total opioid agonist score (16 items) | ClinicalTrials.gov |
| Primary | Opiate-32 Questionnaire, Withdrawal score | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | total opioid withdrawal symptom score (16 items) | ClinicalTrials.gov |
| Primary | Resting-state EEG activation | change from pre- and post-intervention in each of 4 sessions (through study completion, about 1 month total) | relative (gamma band ÷ slow band) ratio in electroencephalogram (EEG) power during resting state | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 5
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Card Sorting Test (Berg) | Primary outcome | ConductCognition |
| Delay Discounting | Primary outcome | ConductCognition |
| Digit Span Test | Primary outcome | ConductCognition |
| Monetary Incentive Delay | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)