Effect of High Intensity Interval Training on Mechanisms of Neuroplasticity in Parkinson's Disease Patients
NCT04204551, Not applicable, Unknown, Wroclaw University of Health and Sport Sciences
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Effect of High Intensity Interval Training on Mechanisms of Neuroplasticity in Parkinson's Disease Patients | ClinicalTrials.gov |
| NCT number | NCT04204551 | ClinicalTrials.gov |
| Status | Unknown | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 60 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Wroclaw University of Health and Sport Sciences | ClinicalTrials.gov |
| Conditions | Parkinson's Disease, Physical Activity, Neurorehabilitation, Neuroplasticity | ClinicalTrials.gov |
| Interventions | high-intensity interval training (HIIT), conventional physical therapy | ClinicalTrials.gov |
| First posted | 2019-12-19 | ClinicalTrials.gov |
| Last updated | 2019-12-24 | ClinicalTrials.gov |
Registered outcomes 113
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Positron Emission Tomography (PET) with 18F-dopa - PET imaging with [18F]fluorodopa uptake. | Pre-HIIT 1 - it means up to 1-week before the HIIT 1 starts | To examine presynaptic striatal DA availability (in dorsal putamen) using PET imaging method with the 18F-dopa - \[18F\]fluorodopa uptake. The recordings will be expressed in Ki ref values \[Ki ref\] and Standard Uptake Values \[SUV\]. | ClinicalTrials.gov |
| Primary | Positron Emission Tomography (PET) with 18F-dopa - PET imaging with [18F]fluorodopa uptake. | 1-week Post-HIIT 1 | To examine presynaptic striatal DA availability (in dorsal putamen) using PET imaging method with the 18F-dopa - \[18F\]fluorodopa uptake. The recordings will be expressed in Ki ref values \[Ki ref\] and Standard Uptake Values \[SUV\]. | ClinicalTrials.gov |
| Primary | Positron Emission Tomography (PET) with 18F-dopa - PET imaging with [18F]fluorodopa uptake. | 3-months Post-HIIT 2 | To examine presynaptic striatal DA availability (in dorsal putamen) using PET imaging method with the 18F-dopa - \[18F\]fluorodopa uptake. The recordings will be expressed in Ki ref values \[Ki ref\] and Standard Uptake Values \[SUV\]. | ClinicalTrials.gov |
| Primary | functional Magnetic Resonance Imaging (fMRI) - metabolic activity of brain recorded with MRI scanner. | Pre-HIIT 1 - it means up to 1-week before the HIIT 1 starts | To evaluate neurophysiological functions of brain subcortical and cortical structures using MRI scanner. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The image recordings will express metabolic brain activity as expressed in fMRI response \[% BOLD signal\]. | ClinicalTrials.gov |
| Primary | functional Magnetic Resonance Imaging (fMRI) - metabolic activity of brain recorded with MRI scanner. | 1-week Post-HIIT 1 | To evaluate neurophysiological functions of brain subcortical and cortical structures using MRI scanner. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The image recordings will express metabolic brain activity as expressed in fMRI response \[% BOLD signal\]. | ClinicalTrials.gov |
| Primary | functional Magnetic Resonance Imaging (fMRI) - metabolic activity of brain recorded with MRI scanner. | 3-months Post-HIIT 2 | To evaluate neurophysiological functions of brain subcortical and cortical structures using MRI scanner. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The image recordings will express metabolic brain activity as expressed in fMRI response \[% BOLD signal\]. | ClinicalTrials.gov |
| Primary | Electroencephalography (EEG) - amplitude of EEG event related potentials of brain cortex recorded from scalp using surface electrodes. | Pre-HIIT 1 - it means up to 1-week before the HIIT1 starts | To evaluate neurophysiological functions of brain cortical structures, electroencephalography (EEG - electrical activity of brain cortex) will be recorded from scalp using 128-chanel system. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The recordings will be analyzed as an amplitude of event related potentials and expressed in microvolts \[µV\]. | ClinicalTrials.gov |
| Primary | Electroencephalography (EEG) - amplitude of EEG event related potentials of brain cortex recorded from scalp using surface electrodes. | 1-week Post-HIIT 1 | To evaluate neurophysiological functions of brain cortical structures, electroencephalography (EEG - electrical activity of brain cortex) will be recorded from scalp using 128-chanel system. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The recordings will be analyzed as an amplitude of event related potentials and expressed in microvolts \[µV\]. | ClinicalTrials.gov |
| Primary | Electroencephalography (EEG) - amplitude of EEG event related potentials of brain cortex recorded from scalp using surface electrodes. | 1.5-month Post-HIIT 1 | To evaluate neurophysiological functions of brain cortical structures, electroencephalography (EEG - electrical activity of brain cortex) will be recorded from scalp using 128-chanel system. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The recordings will be analyzed as an amplitude of event related potentials and expressed in microvolts \[µV\]. | ClinicalTrials.gov |
| Primary | Electroencephalography (EEG) - amplitude of EEG event related potentials of brain cortex recorded from scalp using surface electrodes. | 3-months Post-HIIT 1 | To evaluate neurophysiological functions of brain cortical structures, electroencephalography (EEG - electrical activity of brain cortex) will be recorded from scalp using 128-chanel system. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The recordings will be analyzed as an amplitude of event related potentials and expressed in microvolts \[µV\]. | ClinicalTrials.gov |
| Primary | Electroencephalography (EEG) - amplitude of EEG event related potentials of brain cortex recorded from scalp using surface electrodes. | 1-week Post-HIIT 2 | To evaluate neurophysiological functions of brain cortical structures, electroencephalography (EEG - electrical activity of brain cortex) will be recorded from scalp using 128-chanel system. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The recordings will be analyzed as an amplitude of event related potentials and expressed in microvolts \[µV\]. | ClinicalTrials.gov |
| Primary | Electroencephalography (EEG) - amplitude of EEG event related potentials of brain cortex recorded from scalp using surface electrodes. | 1.5-month Post-HIIT 2 | To evaluate neurophysiological functions of brain cortical structures, electroencephalography (EEG - electrical activity of brain cortex) will be recorded from scalp using 128-chanel system. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The recordings will be analyzed as an amplitude of event related potentials and expressed in microvolts \[µV\]. | ClinicalTrials.gov |
| Primary | Electroencephalography (EEG) - amplitude of EEG event related potentials of brain cortex recorded from scalp using surface electrodes. | 3-months Post-HIIT 2 | To evaluate neurophysiological functions of brain cortical structures, electroencephalography (EEG - electrical activity of brain cortex) will be recorded from scalp using 128-chanel system. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The recordings will be analyzed as an amplitude of event related potentials and expressed in microvolts \[µV\]. | ClinicalTrials.gov |
| Primary | Electroencephalography (EEG) - latency of EEG event related potentials of brain cortex recorded from scalp using surface electrodes. | Pre-HIIT 1 - it means up to 1-week before the HIIT1 starts | To evaluate neurophysiological functions of brain cortical structures, electroencephalography (EEG - electrical activity of brain cortex) will be recorded from scalp using 128-chanel system. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The recordings will be analyzed as a latency of event related potentials and expressed in milliseconds \[ms\]. | ClinicalTrials.gov |
| Primary | Electroencephalography (EEG) - latency of EEG event related potentials of brain cortex recorded from scalp using surface electrodes. | 1-week Post-HIIT 1 | To evaluate neurophysiological functions of brain cortical structures, electroencephalography (EEG - electrical activity of brain cortex) will be recorded from scalp using 128-chanel system. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The recordings will be analyzed as a latency of event related potentials and expressed in milliseconds \[ms\]. | ClinicalTrials.gov |
| Primary | Electroencephalography (EEG) - latency of EEG event related potentials of brain cortex recorded from scalp using surface electrodes. | 1.5-month Post-HIIT 1 | To evaluate neurophysiological functions of brain cortical structures, electroencephalography (EEG - electrical activity of brain cortex) will be recorded from scalp using 128-chanel system. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The recordings will be analyzed as a latency of event related potentials and expressed in milliseconds \[ms\]. | ClinicalTrials.gov |
| Primary | Electroencephalography (EEG) - latency of EEG event related potentials of brain cortex recorded from scalp using surface electrodes. | 3-months Post-HIIT 1 | To evaluate neurophysiological functions of brain cortical structures, electroencephalography (EEG - electrical activity of brain cortex) will be recorded from scalp using 128-chanel system. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The recordings will be analyzed as a latency of event related potentials and expressed in milliseconds \[ms\]. | ClinicalTrials.gov |
| Primary | Electroencephalography (EEG) - latency of EEG event related potentials of brain cortex recorded from scalp using surface electrodes. | 1-week Post-HIIT 2 | To evaluate neurophysiological functions of brain cortical structures, electroencephalography (EEG - electrical activity of brain cortex) will be recorded from scalp using 128-chanel system. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The recordings will be analyzed as a latency of event related potentials and expressed in milliseconds \[ms\]. | ClinicalTrials.gov |
| Primary | Electroencephalography (EEG) - latency of EEG event related potentials of brain cortex recorded from scalp using surface electrodes. | 1.5-month Post-HIIT 2 | To evaluate neurophysiological functions of brain cortical structures, electroencephalography (EEG - electrical activity of brain cortex) will be recorded from scalp using 128-chanel system. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The recordings will be analyzed as a latency of event related potentials and expressed in milliseconds \[ms\]. | ClinicalTrials.gov |
| Primary | Electroencephalography (EEG) - latency of EEG event related potentials of brain cortex recorded from scalp using surface electrodes. | 3-months Post-HIIT 2 | To evaluate neurophysiological functions of brain cortical structures, electroencephalography (EEG - electrical activity of brain cortex) will be recorded from scalp using 128-chanel system. The recordings will be conducted at rest and during self initiated index finger motor task and during mental imagery of this motor task. The recordings will be analyzed as a latency of event related potentials and expressed in milliseconds \[ms\]. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 3
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Trail Making Test A | Primary outcome | ConductCognition |
| Trail Making Test B | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)