Trial · NCT04244981
Efficacy of Prothrombin Complex Concentrate Reducing Perioperative Blood Loss in Cardiac Surgery
NCT04244981, Phase 4, Terminated, SHI Jia
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Efficacy of Prothrombin Complex Concentrate Reducing Perioperative Blood Loss in Cardiac Surgery. Trials, record NCT04244981. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04244981
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Efficacy of Prothrombin Complex Concentrate Reducing Perioperative Blood Loss in Cardiac Surgery
- NCT number
- NCT04244981
- Status
- Terminated
- Phases
- Phase 4
- Enrollment
- 476 participants, actual
- Lead sponsor
- SHI Jia
- Conditions
- Valvular Heart Surgery
- Interventions
- Prothrombin Complex Concentrate, Human, Fresh Frozen Plasma
- First posted
- 2020-01-28
- Last updated
- 2026-06-24
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Cumulative Chest Tube Drainage | between 1 hour after trial drug administration and 24 hours after surgery | cumulative chest tube drainage between 1 hour after trial drug administration and 24 hours after surgery |
| Secondary | Efficacy of Haemostasis | from 1 hour after trial drug administration to 24 hours after surgery | Effectiveness of haemostasis if no hemostatic interventions occurred from 60 minutes to 24 hours after treatment initiation. Hemostatic interventions included surgical reoperation for bleeding, transfusion of any allogeneic blood products (excluding red blood cells), or administration of any coagulation factor concentrate. |
| Secondary | Allogeneic RBCs Units Transfused | between 1 hour after trial drug administration and 24 hours after surgery； and between 1 hour after trial drug administration and 7 days postoperatively | the cumulated allogenic Red blood cells (RBC) units transfused |
| Other | Changes in aPTT, INR, Fibrinogen Levels, Platelet Count, and Hemoglobin | between the preoperative period and the first postoperative morning | Changes in aPTT, INR, fibrinogen levels, platelet count, and hemoglobin between the preoperative period and the first postoperative morning |
| Other | ICU Stay and Total Hospital Stay | from admission to discharge | the length(days) of ICU stay and total hospital stay |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers43
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04244981
GET https://conductscience.org/api/trials/v1/NCT04244981/papers?page=2