Trial · NCT04294966
Age-Related Effects of THC
NCT04294966, Early phase 1, Completed, University of Chicago; results first posted 2023-11-09
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Age-Related Effects of THC. Trials, record NCT04294966. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04294966
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Age-Related Effects of THC
- NCT number
- NCT04294966
- Status
- Completed
- Phases
- Early phase 1
- Enrollment
- 24 participants, actual
- Lead sponsor
- University of Chicago
- Conditions
- Tolerance, Adolescent Behavior, THC
- Interventions
- Dextrose, Dronabinol, Dronabinol
- First posted
- 2020-03-04
- Last updated
- 2023-11-09
- Results first posted
- 2023-11-09
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change From Baseline in Profile of Mood States (POMS) | Through Study Completion, an average of 3 weeks (Baseline - time 0 to Time point 9 (Study Completion)) | The POMS measures individuals' mood states. This is a validated scale to measure positive and negative mood states. The POMS consists of 72 mood adjectives rated on a Likert scale from 0 (not at all) to 4 (extremely), divided into 8 subscales: Friendliness, Anxiety, Elation, Anger, Fatigue, Depression, Confusion and Vigor, and two composite scales: Positive Mood (Elation minus Depression) and Arousal (Vigor plus Anxiety minus Confusion plus Fatigue). Scoring of this instrument provides a global score of 0 to 120 or individual domain scores of 0 to 20. Lower scores indicate better mood state. The POMS brief form is a simple self-rating instrument. |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Change From Baseline in Profile of Mood States (POMS) | Through Study Completion, an average of 3 weeks (Baseline - time 0 to Time point 9 (Study Completion)) | units on a scale | MEAN |
Source ClinicalTrials.gov
Results by group30
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Change From Baseline in Profile of Mood States (POMS) | Placebo | POMS Anxiety Week 1 | 5.75 | Standard Deviation 5.12 | units on a scale |
| Change From Baseline in Profile of Mood States (POMS) | 7.5 mg THC | POMS Anxiety Week 1 | 12.46 | Standard Deviation 3.56 | units on a scale |
| Change From Baseline in Profile of Mood States (POMS) | 15 mg THC | POMS Anxiety Week 1 | 18.55 | Standard Deviation 2.55 | units on a scale |
| Change From Baseline in Profile of Mood States (POMS) | Placebo | POMS Depression Week 1 | 4.08 | Standard Deviation 3.60 | units on a scale |
| Change From Baseline in Profile of Mood States (POMS) | 7.5 mg THC | POMS Depression Week 1 | 5.05 | Standard Deviation 3.66 | units on a scale |
| Change From Baseline in Profile of Mood States (POMS) | 15 mg THC | POMS Depression Week 1 | 6.25 | Standard Deviation 1.05 | units on a scale |
| Change From Baseline in Profile of Mood States (POMS) | Placebo | POMS Vigor Week 1 | 13.00 | Standard Deviation 6.03 | units on a scale |
| Change From Baseline in Profile of Mood States (POMS) | 7.5 mg THC | POMS Vigor Week 1 | 8.05 | Standard Deviation 2.25 | units on a scale |
| Change From Baseline in Profile of Mood States (POMS) | 15 mg THC | POMS Vigor Week 1 | 8.25 | Standard Deviation 4.25 | units on a scale |
| Change From Baseline in Profile of Mood States (POMS) | Placebo | POMS Fatigue Week 1 | 6.67 | Standard Deviation 6.27 | units on a scale |
1 to 10 of 30Source ClinicalTrials.gov
See all 30 results by groupParticipant flow9
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Placebo | 8 | |
| Overall Study | STARTED | 7.5 mg THC | 8 | |
| Overall Study | STARTED | 15 mg THC | 8 | |
| Overall Study | COMPLETED | Placebo | 8 | |
| Overall Study | COMPLETED | 7.5 mg THC | 8 | |
| Overall Study | COMPLETED | 15 mg THC | 8 | |
| Overall Study | NOT COMPLETED | Placebo | 0 | |
| Overall Study | NOT COMPLETED | 7.5 mg THC | 0 | |
| Overall Study | NOT COMPLETED | 15 mg THC | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals9
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Placebo | 0 | 8 |
| Total, all-cause mortality | 7.5 mg THC | 0 | 8 |
| Total, all-cause mortality | 15 mg THC | 0 | 8 |
| Total, other adverse events | Placebo | 0 | 8 |
| Total, other adverse events | 7.5 mg THC | 0 | 8 |
| Total, other adverse events | 15 mg THC | 0 | 8 |
| Total, serious adverse events | Placebo | 0 | 8 |
| Total, serious adverse events | 7.5 mg THC | 0 | 8 |
| Total, serious adverse events | 15 mg THC | 0 | 8 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04294966
GET https://conductscience.org/api/trials/v1/NCT04294966/results?page=2