Trial · NCT04295993
Methylene Blue and Microcirculation in Septic Shock
NCT04295993, Phase 3, Unknown, Cairo University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Methylene Blue and Microcirculation in Septic Shock. Trials, record NCT04295993. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04295993
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Methylene Blue and Microcirculation in Septic Shock
- NCT number
- NCT04295993
- Status
- Unknown
- Phases
- Phase 3
- Enrollment
- 32 participants, estimated
- Lead sponsor
- Cairo University
- Conditions
- Septic Shock
- Interventions
- Methylene Blue, Norepinephrine infusion
- First posted
- 2020-03-05
- Last updated
- 2020-03-05
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Microvascular flow index | 6 hours | The image will be divided into four quadrants and the vessels \<20 μ m diameter will be assigned a score based on the predominant flow characteristics of the vessels in that quadrant (0 = absent flow; 1 = intermittent; 2 = sluggish; 3 = normal). The values in each quadrant will be averaged to give an microvascular flow index for each sublingual site at each time point. To determine heterogeneity of perfusion, the flow heterogeneity index will be calculated as the highest microvascular flow index minus the lowest microvascular flow index divided by the mean microvascular flow index. |
| Secondary | Total vessel density | 6 hours | The number of vessels per millimeters squared. |
| Secondary | Perfused vessel density | 6 hours | The number of vessels multiplied by the fraction of perfused vessels |
| Secondary | Proportion of perfused vessel | 6 hours | The number of vessels with flows 2 and 3 divided by the total number of vessels and multiplied by 100. |
| Secondary | mean arterial pressure | 24 hours | the mean arterial blood pressure measured in mmHg |
| Secondary | serum lactate | 6 hours | the value of lactate in the serum measured in milligrams per liter |
| Secondary | length of stay in the intensive care unit | 28 days | the duration of stay in the intensive care unit measured in days |
| Secondary | cardiac output | 24 hours | The amount of blood ejected by the heart in one minute measured in liters |
| Secondary | total consumption of norepinephrine | 6 hours | the total consumption of norepinephrine in 6 hours measured in micrograms. |
| Secondary | incidence of mortality | 28 days | The number of dead patients divided by the total number of patients |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04295993
GET https://conductscience.org/api/trials/v1/NCT04295993/registered