Trial · NCT04318145
Study to Evaluate Sex Differences in the Acute Effects of PL-3994 in Heart Failure Subjects
NCT04318145, Phase 2, Terminated, Palatin Technologies, Inc
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Study to Evaluate Sex Differences in the Acute Effects of PL-3994 in Heart Failure Subjects. Trials, record NCT04318145. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04318145
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Study to Evaluate Sex Differences in the Acute Effects of PL-3994 in Heart Failure Subjects
- NCT number
- NCT04318145
- Status
- Terminated
- Phases
- Phase 2
- Enrollment
- 15 participants, actual
- Lead sponsor
- Palatin Technologies, Inc
- Conditions
- Heart Failure With Preserved Ejection Fraction
- Interventions
- PL-3994 Aqueous Intravenous Solution Dose Ascention, PL-3994 Aqueous Intravenous Solution Single Dose
- First posted
- 2020-03-23
- Last updated
- 2025-12-15
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Part A: Dose Ascension | 1 day | Reaching the maximum tolderated dose (MTD) as defined by meeting stopping criteria. |
| Primary | Part B: Coronary Sinus Levels | 1 day | Coronary sinus levels of cGMP post PL-3994 infusion as compared to baseline. |
| Secondary | Part B: Blood pressure measured in mmHg | 1 day | Measured at baseline (t=0) and at t=3, 6, 9, 12, and 15 minutes after the infusion of study drug. |
| Secondary | Part B: Heart rate measured in beats per minute | 1 day | Measured at baseline (t=0) and at t=3, 6, 9, 12, and 15 minutes after the infusion of study drug. |
| Secondary | Part B: Right atrial pressure measured in mmHg | 1 day | Measured at baseline (t=0) and at t=3, 6, 9, 12, and 15 minutes after the infusion of study drug. |
| Secondary | Part B: Pulmonary artery pressure measured in mmHg | 1 day | Measured at baseline (t=0) and at t=3, 6, 9, 12, and 15 minutes after the infusion of study drug. |
| Secondary | Part B: Pulmonary capillary wedge pressure measured in mmHg | 1 day | Measured at baseline (t=0) and at t=3, 6, 9, 12, and 15 minutes after the infusion of study drug. |
| Secondary | Part B: Cardiac output measured in L/min. | 1 day | Measured at baseline (t=0) and at t=3, 6, 9, 12, and 15 minutes after the infusion of study drug. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04318145
GET https://conductscience.org/api/trials/v1/NCT04318145/registered