Memory Neuroimaging in Children, Adolescents and Young Adults Following Pediatric Cancer
NCT04324450, Not applicable, Completed, Institut National de la Santé Et de la Recherche Médicale, France
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Memory Neuroimaging in Children, Adolescents and Young Adults Following Pediatric Cancer | ClinicalTrials.gov |
| NCT number | NCT04324450 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 60 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Institut National de la Santé Et de la Recherche Médicale, France | ClinicalTrials.gov |
| Conditions | Cancer Brain, Pediatric Cancer | ClinicalTrials.gov |
| Interventions | MRI, Cognitive assessment | ClinicalTrials.gov |
| First posted | 2020-03-27 | ClinicalTrials.gov |
| Last updated | 2025-09-04 | ClinicalTrials.gov |
Registered outcomes 23
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Structural characteristics of declarative memory neuronal substrate: volume of the hippocampus | Day 1 | Volume of the hippocampus obtained from T1-weighted anatomical | ClinicalTrials.gov |
| Primary | Structural characteristics of declarative memory neuronal substrate: cortical thickness of the hippocampus | Day 1 | Cortical thickness of the hippocampus obtained from T1-weighted anatomical | ClinicalTrials.gov |
| Primary | Structural characteristics of declarative memory neuronal substrate: Microstructural integrity of the hippocampus | Day 1 | Microstructural integrity of the hippocampus obtained from Diffusion Tensor Imaging (DTI) sequences used to calculate the fraction of anisotropy and the mean diffusion sequences | ClinicalTrials.gov |
| Primary | Episodic memory performance | Day 2 | Episodic memory performance of the participants in the different groups when evaluating episodic declarative memory, assessed with Children's Memory Scale in participants under 16 years old and with Wechsler Memory Scale MEM-III in participants over 16 years old (Day 2) | ClinicalTrials.gov |
| Secondary | Declarative episodic memory assessment scores | Day 2 | Scores obtained at memory clinical scale for children | ClinicalTrials.gov |
| Secondary | Declarative semantic memory assessment scores | Day 2 | Scores obtained at Wechsler Intelligence Scale for Children | ClinicalTrials.gov |
| Secondary | Procedural memory assessment scores | Day 2 | Scores obtained at Serial Reaction Time Task | ClinicalTrials.gov |
| Secondary | Short-term auditive memory assessment scores | Day 2 | Scores obtained at Wechsler Intelligence Scale for Children | ClinicalTrials.gov |
| Secondary | Short-term visual memory assessment scores | Day 2 | Scores obtained at Wechsler Memory Scale | ClinicalTrials.gov |
| Secondary | Intellectual capacities assessment scores | Day 2 | Scores obtained at Wechsler Intelligence Scale for Children | ClinicalTrials.gov |
| Secondary | Language assessment scores | Day 2 | Scores obtained at Peabody Picture Vocabulary Test | ClinicalTrials.gov |
| Secondary | Motor functions assessment scores | Day 2 | Scores obtained at Purdue Pegboard Test | ClinicalTrials.gov |
| Secondary | Executive functions assessment scores | Day 2 | Scores obtained at TMT A and B, Stroop Test and Wisconsin Card Sorting Test | ClinicalTrials.gov |
| Secondary | Attentional capacities assessment scores | Day 2 | Scores obtained at Test of Attentional Performance 2.3.1 | ClinicalTrials.gov |
| Secondary | Cerebellar volume | Day 1 | Cerebellar volume obtained from T1-weighted anatomical sequences | ClinicalTrials.gov |
| Secondary | Micro-structural integrity of the cerebellum | Day 1 | Micro-structural integrity of the cerebellum achieved by using DTI sequences to calculate the fraction of anisotropy and average diffusivity | ClinicalTrials.gov |
| Secondary | Cerebral blood volume obtained from brain perfusion imaging | Day 1 | Cerebral blood volume obtained from brain perfusion imaging | ClinicalTrials.gov |
| Secondary | Post-therapeutic hypoxia | Day 1 | Post-therapeutic hypoxia as measured by magnetic resonance spectrometry of the hippocampus and cerebellum | ClinicalTrials.gov |
| Secondary | Neuronal density | Day 1 | Neuronal density as measured by magnetic resonance spectrometry of the hippocampus and cerebellum | ClinicalTrials.gov |
| Secondary | Functional connectivity index | Day 1 | Functional connectivity index, obtained via resting functional MRI. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 4
The papers the trial lists on ClinicalTrials.gov.
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 5
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Card Sorting Test (Berg) | Secondary outcome | ConductCognition |
| Serial Reaction Time | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Vocabulary Test | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)