Trial · NCT04343729
Methylprednisolone in the Treatment of Patients With Signs of Severe Acute Respiratory Syndrome in Covid-19
NCT04343729, Phase 2, Completed, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Methylprednisolone in the Treatment of Patients With Signs of Severe Acute Respiratory Syndrome in Covid-19. Trials, record NCT04343729. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04343729
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Methylprednisolone in the Treatment of Patients With Signs of Severe Acute Respiratory Syndrome in Covid-19
- NCT number
- NCT04343729
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 416 participants, actual
- Lead sponsor
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
- Conditions
- SARS-CoV Infection, Severe Acute Respiratory Syndrome (SARS) Pneumonia
- Interventions
- Methylprednisolone Sodium Succinate, Placebo solution
- First posted
- 2020-04-13
- Last updated
- 2021-07-28
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Mortality rate at day 28 | on day 28, after randomization | Mortality rate on day 28, after randomization |
| Secondary | Mortality rate on days 7, 14 and 28 | after randomization, up to 28 days. | Proportion of patient that died on days 7, 14 and 28. |
| Secondary | Incidence of orotracheal intubation | after randomization, up to 7 days. | proportion of patients requiring orotracheal intubation |
| Secondary | Change in oxygenation index | after randomization, up to 7 days. | Proportion of patients with oxygenation index (PaO2 / FiO2) \< 100 in 7 days. |
| Other | Spirometry (exploratory outcome) | 120 days after randomization | Forced expiratory capacity at the first second of exhalation (FEV1) in liters |
| Other | Spirometry (exploratory outcome) | 120 days after randomization | Forced vital capacity (FVC) in liters |
| Other | Spirometry (exploratory outcome) | 120 days after randomization | FEV1/FVC ratio |
| Other | Spirometry (exploratory outcome) | 120 days after randomization | Forced expiratory flow (FEF) in cmH2O |
| Other | Spirometry (exploratory outcome) | 120 days after randomization | Peak expiratory flow (PEF) in cmH2O |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04343729
GET https://conductscience.org/api/trials/v1/NCT04343729/registered