Trial · NCT04368819
Allopurinol in Patients With Refractory Angina to Improve Ischemic Symptoms
NCT04368819, Phase 2, Phase 3, Unknown, Ministry of Health, Brazil
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Allopurinol in Patients With Refractory Angina to Improve Ischemic Symptoms. Trials, record NCT04368819. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04368819
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Allopurinol in Patients With Refractory Angina to Improve Ischemic Symptoms
- NCT number
- NCT04368819
- Status
- Unknown
- Phases
- Phase 2, Phase 3
- Enrollment
- 40 participants, estimated
- Lead sponsor
- Ministry of Health, Brazil
- Conditions
- Refractory Angina
- Interventions
- Allopurinol 300 MG, Placebo oral tablet
- First posted
- 2020-04-30
- Last updated
- 2021-02-24
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Increase in total exercise time (seconds) assessed by CPET | 16 weeks | Total exercise duration during a maximal, symptom-limited cardiopulmonary exercise testing |
| Secondary | Number of angina attacks per week | 16 weeks | Frequency of patient-reported daily diary of angina |
| Secondary | Short-acting nitrates intake per week | 16 weeks | Frequency of patient-reported short-acting nitrates intake for symptom-relief |
| Secondary | Relative decrease in stress-induced myocardial ischemia during exercise echocardiogram | 16 weeks | % of change in myocardial ischemia burden assessed during exercise echocardiogram stress test compared to baseline |
| Secondary | Relative change in the levels of oxidative stress biomarkers | 16 weeks | % of change in the level of biomarkers of stress oxidative (nitrotyrosine, malondialdehyde and of reduced glutathione) compared to baseline |
| Secondary | Relative change in endothelium-dependent vasodilation during reactive hyperemia in the forearm | 16 weeks | % of improvement in endothelium-dependent vasodilation assessed during reactive hyperemia (brachial artery) compared to baseline |
| Other | Number of participants with treatment-related adverse events as assessed by CTCAE v5.0 | 16 weeks | All AE will be recorded during the 16 week period of the trial |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 20542554 | BACKGROUND |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04368819
GET https://conductscience.org/api/trials/v1/NCT04368819/registered