Trial · NCT04386304
Safety and Biomarker Response to (+)-Epicatechin in Becker Muscular Dystrophy
NCT04386304, Phase 1, Completed, Epirium Bio Inc.
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Safety and Biomarker Response to (+)-Epicatechin in Becker Muscular Dystrophy. Trials, record NCT04386304. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04386304
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Safety and Biomarker Response to (+)-Epicatechin in Becker Muscular Dystrophy
- NCT number
- NCT04386304
- Status
- Completed
- Phases
- Phase 1
- Enrollment
- 22 participants, actual
- Lead sponsor
- Epirium Bio Inc.
- Conditions
- Becker Muscular Dystrophy
- Interventions
- (+)-Epicatechin
- First posted
- 2020-05-13
- Last updated
- 2022-03-23
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of participants with treatment-emergent adverse events (TEAEs) | Through study completion, up to 1 year | The TEAEs will be graded using the adult National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE, Version 5.0). |
| Secondary | Change in cardiac function as assessed by cardiac magnetic resonance imaging (MRI) | Through study completion, up to 1 year | |
| Secondary | Change in cardiac function as assessed by plasma biomarkers [e.g. pro-B-type natriuretic peptide (pro-BNP), nitrates]. | Through study completion, up to 1 year | |
| Secondary | Change in muscle function as assessed by 6-minute walk test (6MWT) | Through study completion, up to 1 year | |
| Secondary | Change in muscle function as assessed by Time to Run/Walk 10-meter Test (TTRW10) | Through study completion, up to 1 year | |
| Secondary | Change in muscle function as assessed by Time to 4-stair Climb Test (TT4SC) | Through study completion, up to 1 year | |
| Secondary | Change in muscle function as assessed by Time to Run/Walk 100-meter Test (TTRW100) | Through study completion, up to 1 year | |
| Secondary | Change in muscle structure and function as assessed by Western blot analysis of biopsy specimens (e.g. dystrophin expression) | Through study completion, up to 1 year | |
| Secondary | Change in muscle biomarkers of regeneration in biopsy specimens (e.g. follistatin) | Through study completion, up to 1 year | |
| Secondary | Change in plasma biomarkers of muscle regeneration (e.g. follistatin, myostatin) | Through study completion, up to 1 year |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04386304
GET https://conductscience.org/api/trials/v1/NCT04386304/registered