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Trial · NCT04400929

Using GM-CSF as a Host Directed Therapeutic Against COVID-19

NCT04400929, Phase 2, Completed, Singapore General Hospital

3 sourcestrials-2026-11-12-0.5.0

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ConductScience Library. Using GM-CSF as a Host Directed Therapeutic Against COVID-19. Trials, record NCT04400929. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04400929

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Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title
Using GM-CSF as a Host Directed Therapeutic Against COVID-19
NCT number
NCT04400929
Status
Completed
Phases
Phase 2
Enrollment
2 participants, actual
Lead sponsor
Singapore General Hospital
Conditions
COVID, Sars-CoV2, ARDS, Human
Interventions
Sargramostim, Normal Saline 0.9%
First posted
2020-05-26
Last updated
2022-05-10

Source ClinicalTrials.gov

Registered outcomes1

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

ListOutcomeTime frameDescription
PrimaryMeasuring oxygenationDay 1 to Day 6
To measure the effectiveness of Leukine® in restoring lung homeostasis, the primary endpoint of this intervention is measuring oxygenation after 5 days of intravenous treatment through assessment of pre-treatment and post-treatment ratio of PaO2/FiO2, and through measurement of the P(A-a)O2 gradient, which can easily be performed in the setting of clinical observation of inpatients.

Outcomes0

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

None in this release.

Results by group0

Each measurement the trial posted, group by group, in the words and numbers it posted.

None in this release.

Participant flow0

How many started, completed or left each group, period by period.

None in this release.

Adverse events0

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

None in this release.

Adverse event totals0

The totals the trial posted for each group.

None in this release.

Papers30

The papers the trial lists on ClinicalTrials.gov.

PMIDListed asSource
6476079BACKGROUNDPubMed
8180384BACKGROUNDPubMed
8201000BACKGROUNDPubMed
11179099BACKGROUNDPubMed
11734443BACKGROUNDPubMed
12119223BACKGROUNDPubMed
15919935BACKGROUNDPubMed
16741700BACKGROUNDPubMed
19590022BACKGROUNDPubMed
20167854BACKGROUNDPubMed

1 to 10 of 30

See all 30 papers

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons0

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

None in this release.

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov
2026-11-12
ClinicalTrials.gov
Results, from AACT
2026-03-23
AACT
NIH grant links
2026-11-13
NIH RePORTER

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT04400929

GET https://conductscience.org/api/trials/v1/NCT04400929/papers?page=2