Trial · NCT04426968
A Phase II Study of Hepalatide in Subjects With Chronic Hepatitis B
NCT04426968, Phase 2, Completed, Shanghai HEP Pharmaceutical Co., Ltd.
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Phase II Study of Hepalatide in Subjects With Chronic Hepatitis B. Trials, record NCT04426968. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04426968
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Phase II Study of Hepalatide in Subjects With Chronic Hepatitis B
- NCT number
- NCT04426968
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 96 participants, actual
- Lead sponsor
- Shanghai HEP Pharmaceutical Co., Ltd.
- Conditions
- Hepatitis B, Chronic
- Interventions
- Hepalatide 2.1mg, Hepalatide 4.2mg, Hepalatide 6.3mg, placebo 2.1mg, placebo 4.2mg, placebo 6.3mg, Pegylated Interferon
- First posted
- 2020-06-11
- Last updated
- 2025-01-27
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | virological response | 24weeks | |
| Secondary | HBV DNA down from baseline | 24weeks | HBV DNA down from baseline log10 |
| Other | Virological suppression | 24weeks | HBV DNA \<2,000 IU/ml |
| Other | No response | 24weeks | HBsAg \>20,000 IU/ml and HBV DNA lower than baseline \<2log10 IU/ml |
| Other | Partial virological response | 24weeks | HBV DNA \>20 IU/ml and ≥2log10 IU/ml lower than baseline |
| Other | HBsAg is down from baseline | 24weeks | HBsAg is down from baseline log10 |
| Other | HBeAg turned negative | 24weeks | HBeAg \<0.05 index |
| Other | HBeAg is down from baseline | 24weeks | HBeAg is down from baseline log10 |
| Other | ALT recurrence | 24weeks | ALT≤1.25×ULN |
| Other | Histological response | 24weeks | Liver tissue inflammatory necrosis score reduced by ≥2 points with no increased liver fibrosis score; liver fibrosis score reduced by ≥1 point |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04426968
GET https://conductscience.org/api/trials/v1/NCT04426968/registered