Novel Dementia Biomarkers
NCT04427436, Unknown, German Center for Neurodegenerative Diseases (DZNE)
Trial 9
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Novel Dementia Biomarkers | ClinicalTrials.gov |
| NCT number | NCT04427436 | ClinicalTrials.gov |
| Status | Unknown | ClinicalTrials.gov |
| Enrollment | 100 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | German Center for Neurodegenerative Diseases (DZNE) | ClinicalTrials.gov |
| Conditions | Alzheimer Disease, Early Onset | ClinicalTrials.gov |
| Interventions | No Intervention | ClinicalTrials.gov |
| First posted | 2020-06-11 | ClinicalTrials.gov |
| Last updated | 2020-06-11 | ClinicalTrials.gov |
Registered outcomes 9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Locus Coeruleus (LC) Intensity | 15 minutes | LC-intensity can be assesed with specific MRI sequences (TSE MRI-Sequence (see Dordevic et al, 2017)) | ClinicalTrials.gov |
| Primary | Volume of brain regions | 30 minutes | VBM (voxel-based morphometry) | ClinicalTrials.gov |
| Primary | fNIRS-based change in oxyhemoglobin and deoxyhemoglobin | 1 hour | In response to each task there is a hemodynamic response, which can be measured by fNIRS. In particular, fNIRS measures changes in blood oxy- and deoxy-hemoglobin. | ClinicalTrials.gov |
| Primary | Event-related-potential (ERP) waveforms: negative deflections (N100, N300) and positive deflections (P100, P300) | 1 hour | Voltages generated in the brain structures in response to specific events (Event-related potentials (ERPs)) | ClinicalTrials.gov |
| Primary | Heart Rate Variability (HRV) | 1 hour | ECG-based variability measures in R-R intervals, both in rest abd during tasks | ClinicalTrials.gov |
| Primary | Score on CERAD-Plus | 30 minutes | Cognitive performance measure in points, with a higher score meaning better performance | ClinicalTrials.gov |
| Primary | Error-rate on Stroop-test | 10 minutes | Test of executive functions, higher error-rate means worse performance | ClinicalTrials.gov |
| Primary | Error-rate on N-Back-test | 10 minutes | Working memory test, higher error-rate means worse performance | ClinicalTrials.gov |
| Primary | Performance on verbal fluency test | 10 minutes | Test of verbal fluency, more words spoken means a better score | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 34035103 | DERIVED | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 4
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| 1-Back Task | Primary outcome | ConductCognition |
| 2-Back Task | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Verbal Fluency | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)