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Trial · NCT04434092

Results by group83

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
Percentage of Participants With Transfusion Avoidance (TA)Arm A: Crovalimab65.795% Confidence Interval 56.91 to 73.52percentage of participants
Percentage of Participants With Transfusion Avoidance (TA)Arm B: Eculizumab68.195% Confidence Interval 55.67 to 78.53percentage of participants
Percentage of Participants With Hemolysis Control Measured by LDHArm A: Crovalimab79.395% Confidence Interval 72.86 to 84.48percentage of participants
Percentage of Participants With Hemolysis Control Measured by LDHArm B: Eculizumab79.095% Confidence Interval 69.66 to 85.99percentage of participants
Percentage of Participants With Breakthrough Hemolysis (BTH)Arm A: Crovalimab10.495% Confidence Interval 6.04 to 17.21percentage of participants
Percentage of Participants With Breakthrough Hemolysis (BTH)Arm B: Eculizumab14.595% Confidence Interval 7.54 to 25.50percentage of participants
Percentage of Participants With Stabilization of HemoglobinArm A: Crovalimab63.495% Confidence Interval 54.63 to 71.45percentage of participants
Percentage of Participants With Stabilization of HemoglobinArm B: Eculizumab60.995% Confidence Interval 48.35 to 72.17percentage of participants
Change From Baseline in Fatigue Assessed by Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) ScaleArm A: CrovalimabBaseline36.02Standard Error 0.877score on scale
Change From Baseline in Fatigue Assessed by Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) ScaleArm B: EculizumabBaseline35.09Standard Error 1.408score on scale
Change From Baseline in Fatigue Assessed by Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) ScaleArm A: CrovalimabChange at Week 257.79Standard Error 0.661score on scale
Change From Baseline in Fatigue Assessed by Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) ScaleArm B: EculizumabChange at Week 255.15Standard Error 0.880score on scale
Change From Baseline in Absolute Reticulocyte CountArm A: CrovalimabBaseline2865.56Standard Deviation 22637.2410^9 cells/liter (L)
Change From Baseline in Absolute Reticulocyte CountArm B: EculizumabBaseline164.26Standard Deviation 114.2710^9 cells/liter (L)
Change From Baseline in Absolute Reticulocyte CountArm A: CrovalimabChange at Week 1 Day 1-58.50Standard Deviation NA10^9 cells/liter (L)
Change From Baseline in Absolute Reticulocyte CountArm A: CrovalimabChange at Week 2542.90Standard Deviation 4314.0710^9 cells/liter (L)
Change From Baseline in Absolute Reticulocyte CountArm B: EculizumabChange at Week 2105.88Standard Deviation 601.7710^9 cells/liter (L)
Change From Baseline in Absolute Reticulocyte CountArm A: CrovalimabChange at Week 3-71.08Standard Deviation 533.0110^9 cells/liter (L)
Change From Baseline in Absolute Reticulocyte CountArm B: EculizumabChange at Week 3-15.62Standard Deviation 53.7910^9 cells/liter (L)
Change From Baseline in Absolute Reticulocyte CountArm A: CrovalimabChange at Week 48.52Standard Deviation 58.0110^9 cells/liter (L)

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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