Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive Disorder
NCT04466345, Phase 2, Completed, University Health Network, Toronto
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive Disorder | ClinicalTrials.gov |
| NCT number | NCT04466345 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Phase 2 | ClinicalTrials.gov |
| Enrollment | 72 participants, actual | ClinicalTrials.gov |
| Lead sponsor | University Health Network, Toronto | ClinicalTrials.gov |
| Conditions | Major Depressive Disorder | ClinicalTrials.gov |
| Interventions | Semaglutide, Placebo | ClinicalTrials.gov |
| First posted | 2020-07-10 | ClinicalTrials.gov |
| Last updated | 2025-10-02 | ClinicalTrials.gov |
Registered outcomes 16
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Executive Function Composite Score | 16 Weeks | The primary outcome will be an executive function composite score. This score will be comprised of the Digit Symbol Substitution Test (DSST - number of symbols), the Stroop test (time to completion in the congruent and incongruent conditions), and the Spatial n-back (reaction times and accuracy in four conditions,1-back, 2-back, 3-back, and 4-back). | ClinicalTrials.gov |
| Secondary | Digit Symbol Substitution Test (DSST) | 16 Weeks | DSST is a neurocognitive test designed to assess motor speed and concentration. | ClinicalTrials.gov |
| Secondary | Rey Auditory Verbal Learning Test (RAVLT) | 16 Weeks | RAVLT is a neurocognitive test designed to assess verbal learning and memory. | ClinicalTrials.gov |
| Secondary | Stroop Test | 16 Weeks | The Stroop Test is a neurocognitive test designed to assess the ability to inhibit cognitive interference. | ClinicalTrials.gov |
| Secondary | Trail Making Test A (TMTA) | 16 Weeks | TMTA is a neurocognitive test designed to assess visual scanning and attention. | ClinicalTrials.gov |
| Secondary | Perceived Deficits Questionnaire (PDQ) | 16 Weeks | PDQ is used to assess subjective cognitive dysfunction. | ClinicalTrials.gov |
| Secondary | 36-Item Short Form Health Survey (SF-36) | 16 Weeks | SF-36 is used to assess quality of life. | ClinicalTrials.gov |
| Secondary | Sheehan Disability Scale (SDS) | 12 Weeks | SDS is used to assess functional impairment in work/school, social life, and family life. | ClinicalTrials.gov |
| Secondary | Endicott Workplace Productivity Scale (EWPS) | 16 Weeks | EWPS is used to assess workplace productivity. | ClinicalTrials.gov |
| Secondary | Height | 16 Weeks | Unit: cm | ClinicalTrials.gov |
| Secondary | Weight | 16 Weeks | Unit: kg | ClinicalTrials.gov |
| Secondary | fasting glucose - Blood laboratorial marker | 16 Weeks | ClinicalTrials.gov | |
| Secondary | Diet History Questionnaire III (DHQ) | 16 Weeks | DHQ is a freely available questionnaire used to assess dietary intake (https://epi.grants.cancer.gov/dhq3/). | ClinicalTrials.gov |
| Secondary | Physical Activity Questionnaire (IPAQ) | 16 Weeks | IPAQ is used to assess physical activity. | ClinicalTrials.gov |
| Secondary | Pittsburgh Sleep Quality Index (PSQI) | 16 Weeks | PSQI is used to assess sleep quality. | ClinicalTrials.gov |
| Secondary | Trail Making Test B (TMTB) | 16 Weeks | TMTB is a neurocognitive test designed to assess attention and concentration. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 2
The papers the trial lists on ClinicalTrials.gov.
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 8
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| 1-Back Task | Primary outcome | ConductCognition |
| 2-Back Task | Primary outcome | ConductCognition |
| Spatial N-Back Task | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Symbol Coding | Primary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
| Verbal Learning | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)