Trial · NCT04533997
Hypertonic Saline Therapy in Ambulatory Heart Failure Unit.
NCT04533997, Phase 3, Completed, Puerta de Hierro University Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Hypertonic Saline Therapy in Ambulatory Heart Failure Unit. Trials, record NCT04533997. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04533997
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Hypertonic Saline Therapy in Ambulatory Heart Failure Unit.
- NCT number
- NCT04533997
- Status
- Completed
- Phases
- Phase 3
- Enrollment
- 167 participants, actual
- Lead sponsor
- Puerta de Hierro University Hospital
- Conditions
- Heart Failure
- Interventions
- Hypertonic saline solution plus intravenous furosemide, Intravenous furosemide
- First posted
- 2020-09-01
- Last updated
- 2023-11-09
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Diuresis volume (ml) | 3 hours after treatment | Total diuresis volume after 3 hours of therapy administration |
| Secondary | Weight difference (kg) | 3 hours | Difference of weight 3 hours after the start of treatment |
| Secondary | Weight difference (kg) | 7 days | Difference of weight 7 days after the start of treatment |
| Secondary | Change in composite congestion score | 7 days | Composite of orthopnoea (0-3), jugular venous distension (0-3), lower limb oedema (0-3). Higher score: worse congestion |
| Secondary | Change in Inferior cava vein diameter (mm) | 7 days | Change in Inferior cava vein diameter (mm) 7 days after treatment |
| Secondary | Change in Number of fields with more than 3 B-lines in lung ultrasound | 7 days | Change in Number of fields with more than 3 B-lines in lung ultrasound 7 days after treatment |
| Secondary | Change in New York Heart Association and Visual Analogue Scale | 7 days | Visual Analogue Scale from 0 (worst state of health) to 100 (best state of health) |
| Secondary | Change in NTproBNP and Cancer Antigen 125 levels | 7 days | Change in NTproBNP and Cancer Antigen 125 levels 7 days after treatment |
| Secondary | Change in Hemoconcentration Parameters | 7 days | Hematocrit, Albumin and total Proteins |
| Secondary | Change in Urinary Sodium | 7 days | Change in Urinary Sodium measured in a spot urinary sample |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04533997
GET https://conductscience.org/api/trials/v1/NCT04533997/registered