Trial · NCT04573751
The EPIVER Randomized Controlled Trial
NCT04573751, Not applicable, Completed, Tomsk National Research Medical Center of the Russian Academy of Sciences
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The EPIVER Randomized Controlled Trial. Trials, record NCT04573751. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT04573751
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The EPIVER Randomized Controlled Trial
- NCT number
- NCT04573751
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 104 participants, actual
- Lead sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
- Conditions
- ST Elevation Myocardial Infarction, Percutaneous Coronary Intervention, No-Reflow Phenomenon
- Interventions
- Standard therapy, Epinephrine, Verapamil, Epinephrine + verapamil
- First posted
- 2020-10-05
- Last updated
- 2026-06-24
Source ClinicalTrials.gov
Registered outcomes14
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Mortality | month 1 | Mortality rate (percent) |
| Primary | New onset or worsening acute heart failure | month 1 | The rate (percent) of patients experiencing new onset or worsening acute heart failure. Congestion characterized by dyspnea, edema, rales, jugular venous distention and need to increase diuretic doses is a hallmark of acute heart failure prompting hospitalization |
| Secondary | Thrombolysis in myocardial infarction (TIMI) 3 | hour 1 | The rate of patients (percent) who achieved TIMI 3 coronary blood flow after percutaneous coronary intervention |
| Secondary | Change in systolic/diastolic blood pressure | minute 3 | Change in systolic/diastolic blood pressure values (mmHg) before and after intracoronary verapamil/epinephrine |
| Secondary | ST segment resolution | hour 72 | Degree of ST segment resolution on ECG (mm) |
| Secondary | Troponin I release | hour 72 | Concentration of troponin I (ng/mL) |
| Secondary | LV EF | day 10 | Left ventricular ejection fraction (LV EF) (percent) |
| Secondary | Myocardial injury | day 2 | Total volume (mL) of microvascular obstruction, myocardial necrosis, edema, and hemorrhagic impregnation according to MRI data |
| Secondary | SPECT-based coronary reserve | day 7 | Coronary reserve will be measured by cardiac single photon emission computed tomography (SPECT) with technetium-99m-labeled methoxy-isobutyl isonitrile (99mТсMIBI) at rest and during pharmacological stress-test (counts) |
| Secondary | Change in heart rate values | minute 3 | Change in heart rate values (beat per minute) before and after intracoronary verapamil/epinephrine |
1 to 10 of 14Source ClinicalTrials.gov
See all 14 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 40846132 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT04573751
GET https://conductscience.org/api/trials/v1/NCT04573751/registered